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DOI	10.3390/molecules28062579
	Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil
	Zhang, Manyu; Ren, Jinwei; Luo, Yuanming; Xie, Weidong; Li, Erwei
发表日期	2023
EISSN	1420-3049
卷号	28 期号:6
英文摘要	Six new polyene carboxylic acids named serpentemycins E-J (1-6), together with three known analogs (7-9), were isolated from the fermentation medium of Streptomyces sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds 1-9 against NO production in LPS-activated RAW264.7 cells were evaluated. Compound 9 has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 mu M.
关键词	polyene carboxylic acid secondary metabolites bioactivity NO production
英文关键词	NATURAL-PRODUCTS; JAPONICUM
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000958780700001
来源期刊	MOLECULES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282982
作者单位	Shandong University; Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; Institute of Microbiology, CAS
推荐引用方式 GB/T 7714	Zhang, Manyu,Ren, Jinwei,Luo, Yuanming,et al. Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil[J],2023,28(6).
APA	Zhang, Manyu,Ren, Jinwei,Luo, Yuanming,Xie, Weidong,&Li, Erwei.(2023).Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil.MOLECULES,28(6).
MLA	Zhang, Manyu,et al."Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil".MOLECULES 28.6(2023).