气候变化领域集成服务门户(CCPortal): Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single-center retrospective study of Tibet

CCPortal

DOI	10.1007/s00415-023-11597-2
	Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single-center retrospective study of Tibet
	Sha, Yuhui; Ci, Yang; Cidan, Zhuoga; Zhao, Yuhua; Zhou, Lixin; Ni, Jun
发表日期	2023
ISSN	0340-5354
EISSN	1432-1459
起始页码	2688
结束页码	2692
卷号	270 期号:5
英文摘要	ObjectiveData regarding diagnosis, management, and prognosis of patients with cerebral venous thrombosis (CVT) from high altitude are limited. The aim of the present study is to identify the clinical features, risk factors, and outcomes of cerebral venous thrombosis (CVT) in Tibet.MethodsWe retrospectively included patients with a diagnosis of CVT consecutively admitted to Tibet Autonomous Region People's Hospital between July 2015, and September 2022. The risk factors, clinical and radiological presentations, treatment and outcomes were analyzed.ResultsA total of 38 patients with CVT were included in this study. The median age was 31 years, and females accounted for 63.2%. Patients of Tibetan nationality accounted for 71.1% (n = 27) and the median altitude of residence in Tibet was 3800 m (3657, 4054). Headache was the most common symptom (92.1%). The most common risk factors of CVT were infection in the past 4 weeks (34.2%) and pregnancy or puerperium (23.7%). Lateral sinus (transverse and/or sigmoid sinus) (68.4%) and superior sagittal sinus (55.3%) were the most commonly involved. The D-dimer increased in 31 patients (81.6%). All three patients who died in hospital and during follow-up had risk factor of recent infection. Favorable outcome at follow-up with a median length of 454 days (189, 1059) was observed in 85.3% of patients.ConclusionsCVT at high altitude is more common in young patients and women, with various clinical manifestations and risk factors. Recent infection is the most common risk factor and may increase the mortality of CVT at high altitude. The long-term prognosis of CVT at high altitude is favorable.
关键词	Cerebral vascular thrombosis High altitude Risk factors Prognosis
WOS研究方向	Clinical Neurology
WOS记录号	WOS:000928734200001
来源期刊	JOURNAL OF NEUROLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282971
作者单位	Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital
推荐引用方式 GB/T 7714	Sha, Yuhui,Ci, Yang,Cidan, Zhuoga,et al. Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single-center retrospective study of Tibet[J],2023,270(5).
APA	Sha, Yuhui,Ci, Yang,Cidan, Zhuoga,Zhao, Yuhua,Zhou, Lixin,&Ni, Jun.(2023).Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single-center retrospective study of Tibet.JOURNAL OF NEUROLOGY,270(5).
MLA	Sha, Yuhui,et al."Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single-center retrospective study of Tibet".JOURNAL OF NEUROLOGY 270.5(2023).