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DOI	10.1186/s12870-023-04219-6
	Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet
	Liu, Xinyu; Renzengwangdui, Shiyu; Tang, Shiyu; Zhu, Yiru; Wang, Meng; Cao, Binqian; Wang, Jinglong; Zhao, Baoyu; Lu, Hao
发表日期	2023
ISSN	1471-2229
卷号	23 期号:1
英文摘要	BackgroundArtemisia is important medicinal plants in China and are widely used in medicine, agriculture, and food. Pharmacologically active components of the plants remain to be investigated.MethodsThis study sought to identify and compare the chemical constituents of three species of Artemisia in Tibet using a widely-targeted metabolomics approach and their antibacterial and antioxidant capacities were determined.ResultA total of 1109 metabolites within 10 categories were detected from the three species of Artemisia, including lipids, amino acids, nucleotides, flavonoids, terpenes, coumarins, organic acids, and phenolic acids. 732 different metabolites have been identified between Artemisia sieversiana and Artemisia annua, 751 different metabolites were identified between Artemisia wellbyi and A. sieversiana, and 768 differential metabolites were differentially detected from A. wellbyi and A. annua. Differentially identified compounds included flavonoids, phenolic acids, artemisinins and coumarin. A. annua contained the highest relative content of artemisinin among three Artemisia. The antimicrobial experiments showed that the three Artemisia species had strong antibiotic activities against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Proteus mirabilis and Pseudomonas aeruginosa. The biochemical analysis showed that the three species of Artemisia have strong antioxidant capacity.ConclusionsThis is the first reported attempt to comparatively determine the types of the metabolites of the three widely distributed Artemisia species in Tibet. The information should help medicinal research and facilitate comprehensive development and utilization of Artemisia species in Tibet.
关键词	Artemisia Mmetabolomic analysis Antibacterial activity Antioxidant activity
英文关键词	ESSENTIAL OIL; L.; IDENTIFICATION; CONSTITUENTS; FLAVONOIDS; EXTRACT
WOS研究方向	Plant Sciences
WOS记录号	WOS:000973806400001
来源期刊	BMC PLANT BIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282879
作者单位	Northwest A&F University - China; Tibet Academy of Agriculture & Animal Husbandry Sciences
推荐引用方式 GB/T 7714	Liu, Xinyu,Renzengwangdui, Shiyu,Tang, Shiyu,et al. Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet[J],2023,23(1).
APA	Liu, Xinyu.,Renzengwangdui, Shiyu.,Tang, Shiyu.,Zhu, Yiru.,Wang, Meng.,...&Lu, Hao.(2023).Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet.BMC PLANT BIOLOGY,23(1).
MLA	Liu, Xinyu,et al."Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet".BMC PLANT BIOLOGY 23.1(2023).