气候变化领域集成服务门户(CCPortal): The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau

CCPortal

DOI	10.1002/ece3.10387
	The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau
	Liang, Junrong; Duan, Ran; Qin, Shuai; Lv, Dongyue; He, Zhaokai; Zhang, Haoran; Duan, Qun; Xi, Jinxiao; Chun, Hua; Fu, Guoming; Zheng, Xiaojin; Tang, Deming; Wu, Weiwei; Han, Haonan; Jing, Huaiqi; Wang, Xin
发表日期	2023
ISSN	2045-7758
卷号	13 期号:8
英文摘要	Plague is a typical natural focus disease that circulates in different ecology of vectors and reservoir hosts. We conducted genomic population and phylogenetic analyses of the Yersinia pestis collected from the 12 natural plague foci in China with more than 20 kinds of hosts and vectors. Different ecological landscapes with specific hosts, vectors, and habitat which shape various niches for Y. pestis. The phylogeographic diversity of Y. pestis in different kinds plague foci in China showed host niches adaptation. Most natural plague foci strains are region-and focus-specific, with one predominant subpopulation; but the isolates from the Qinghai-Tibet plateau harbor a higher genetic diversity than other foci. The Y. pestis from Marmota himalayana plague foci are defined as the ancestors of different populations at the root of the evolutionary tree, suggesting several different evolutionary paths to other foci. It has the largest pan-genome and widest SNP distances with most accessory genes enriched in mobilome functions (prophages, transposons). Geological barriers play an important role in the maintenance of local Y. pestis species and block the introduction of non-native strains. This study provides new insights into the control of plague outbreaks and epidemics, deepened the understanding of the evolutionary history of MHPF (M. himalayana plague focus) in China. The population structure and identify clades among different natural foci of China renewed the space cognition of the plague.
关键词	phylogenetic analysis plague natural foci Qinghai-Tibet plateau SNP typing
英文关键词	PNEUMONIC PLAGUE; PROVINCE; AGENT; DNA
WOS研究方向	Ecology ; Evolutionary Biology
WOS记录号	WOS:001038861800001
来源期刊	ECOLOGY AND EVOLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282790
作者单位	Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention
推荐引用方式 GB/T 7714	Liang, Junrong,Duan, Ran,Qin, Shuai,et al. The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau[J],2023,13(8).
APA	Liang, Junrong.,Duan, Ran.,Qin, Shuai.,Lv, Dongyue.,He, Zhaokai.,...&Wang, Xin.(2023).The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau.ECOLOGY AND EVOLUTION,13(8).
MLA	Liang, Junrong,et al."The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau".ECOLOGY AND EVOLUTION 13.8(2023).