气候变化领域集成服务门户(CCPortal): Structure and Metabolic Characteristics of Intestinal Microbiota in Tibetan and Han Populations of Qinghai-Tibet Plateau and Associated Influencing Factors

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DOI	10.3390/microorganisms11112655
	Structure and Metabolic Characteristics of Intestinal Microbiota in Tibetan and Han Populations of Qinghai-Tibet Plateau and Associated Influencing Factors
	Lv, Jin; Qi, Ping; Yan, Xiangdong; Bai, Liuhui; Zhang, Lei
发表日期	2023
EISSN	2076-2607
卷号	11 期号:11
英文摘要	Residents of the Qinghai-Tibet Plateau might experience shifts in their gut microbiota composition as a result of the plateau environment. For example, high altitudes can increase the abundance of obligate anaerobic bacteria, decrease the number of aerobic bacteria and facultative anaerobic bacteria, increase probiotics, and decrease pathogenic bacteria. This study aimed to determine the structure and metabolic differences in intestinal microbial communities among the Tibetan and Han populations on the Qinghai-Xizang Plateau and shed light on the factors that influence the abundance of the microbial communities in the gut. The structural characteristics of intestinal microorganisms were detected from blood and fecal samples using 16S rRNA sequencing. Metabolic characteristics were detected using gas chromatography-time-of-flight mass spectrometry (GC-TOFMS). The influencing factors were analyzed using Spearman's correlation analysis. Bacteroides and Bifidobacterium were dominant in the intestinal tract of the Han population, while Bacteroides and Prevotella were dominant in that of the Tibetan population, with marked differences in Pseudomonas, Prevotella, and other genera. Ferulic acid and 4-methylcatechol were the main differential metabolites between the Tibetan and Han ethnic groups. This may be the reason for the different adaptability of Tibetan and Han nationalities to the plateau. Alanine aminotransferase and uric acid also have a high correlation with different bacteria and metabolites, which may play a role. These results reveal notable disparities in the compositions and metabolic characteristics of gut microbial communities in the Tibetan and Han people residing on the Qinghai-Tibet Plateau and may provide insights regarding the mechanism of plateau adaptability.
关键词	Qinghai-Tibet Plateau intestinal microorganisms Tibetans Han nationality metabolomics
英文关键词	HIGH-ALTITUDE ADAPTATION; GUT MICROBIOME; HYPOXIA; DAMAGE
WOS研究方向	Microbiology
WOS记录号	WOS:001113836100001
来源期刊	MICROORGANISMS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282737
作者单位	Lanzhou University; Lanzhou University; Lanzhou University
推荐引用方式 GB/T 7714	Lv, Jin,Qi, Ping,Yan, Xiangdong,et al. Structure and Metabolic Characteristics of Intestinal Microbiota in Tibetan and Han Populations of Qinghai-Tibet Plateau and Associated Influencing Factors[J],2023,11(11).
APA	Lv, Jin,Qi, Ping,Yan, Xiangdong,Bai, Liuhui,&Zhang, Lei.(2023).Structure and Metabolic Characteristics of Intestinal Microbiota in Tibetan and Han Populations of Qinghai-Tibet Plateau and Associated Influencing Factors.MICROORGANISMS,11(11).
MLA	Lv, Jin,et al."Structure and Metabolic Characteristics of Intestinal Microbiota in Tibetan and Han Populations of Qinghai-Tibet Plateau and Associated Influencing Factors".MICROORGANISMS 11.11(2023).