气候变化领域集成服务门户(CCPortal): Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study

CCPortal

DOI	10.1515/biol-2022-0740
	Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study
	Yuan, Xiaoyong; Lu, Difei; Meng, Shuyou; Yang, Lihui; Yuan, Geheng; Qi, Xin; Wen, Bing; Zhang, Junqing; Guo, Xiaohui
发表日期	2023
ISSN	2391-5412
卷号	18 期号:1
英文摘要	The objective of this study was to explore the clinical characteristics and prognosis of diabetic foot in hospitalized patients with diabetes in Tibet. To achieve that, patients hospitalized in People's Hospital of Tibet Autonomous Region and diagnosed with diabetic foot ulcer (DFU) from January 1, 2016 to December 31, 2020 were enrolled in the study, and DFU cases of Peking University First Hospital were collected as control group. Analysis and comparison of clinical characteristics of DFU in plateau and plain areas were conducted. Normal distribution data or non-normal distribution data between groups were analyzed by t-test analysis or the nonparametric Mann-Whitney U test, and categorical variants were compared by Chi-square of Pearson. A total of 54 DFU cases were enrolled in the study in the People's Hospital of Tibet Autonomous Region (Tibet group for short). Males accounted for 83.3% (45 cases) in Tibet group, which was higher than that of Peking University First Hospital (Beijing group for short), which accounted for 67.0%. Compared with the DFU patients in the Beijing group, the Tibet group was younger (58.11 +/- 12.25 years vs 64.18 +/- 11.37 years, P < 0.05), with a shorter disease duration (7.00 years vs 12.00 years, P < 0.05). In contrast, alcohol consumption was higher in the Tibet group (44.4 vs 27.4%, P < 0.05), and the number of patients with smoking habit was higher in the Beijing group (29.6 vs 43.7%, P < 0.05). The Tibet group had higher HbA1c (10.2 vs 8.7%, P < 0.05) and lower DFU proportion (22.2 vs 44.2%, P < 0.05). There was no statistically significant difference in the proportion of moderate to severe infections between the two groups (58.5 vs 59.6%, P = 0.887). Leukocytes (6.75 x 10(9)/L vs 8.72 x 10(9)/L, P < 0.05) and neutrophils (4.07 x 10(9)/L vs 6.26 x 10(9)/L, P < 0.05) in Tibet group were lower. Although the DFU amputation rate in the Tibet group was lower than that in the Beijing group (9.3 vs 29.8%, P < 0.05), there was no statistically significant difference between the two groups in terms of treatment cost, hospital stay, and mortality. In conclusion, patients with DFU in Tibet had a smaller age, shorter duration of diabetes, and more male predominance. The proportions of gangrene and amputation were lower in Tibet, with gangrene accounting for 80% of all amputees.
关键词	region differences diabetic foot infection amputation death rate
WOS研究方向	Biology
WOS记录号	WOS:001087091400001
来源期刊	OPEN LIFE SCIENCES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282729
作者单位	Peking University
推荐引用方式 GB/T 7714	Yuan, Xiaoyong,Lu, Difei,Meng, Shuyou,et al. Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study[J],2023,18(1).
APA	Yuan, Xiaoyong.,Lu, Difei.,Meng, Shuyou.,Yang, Lihui.,Yuan, Geheng.,...&Guo, Xiaohui.(2023).Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study.OPEN LIFE SCIENCES,18(1).
MLA	Yuan, Xiaoyong,et al."Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study".OPEN LIFE SCIENCES 18.1(2023).