气候变化领域集成服务门户(CCPortal): Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment

CCPortal

DOI	10.1080/10495398.2023.2258953
	Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment
	An, Li; Li, Yanyan; Yaq, Lin; Wang, Yong; Dai, Qilin; Du, Shizhang; Ru, Yi; Zhoucuo, Qi; Wang, Jinling
发表日期	2023
ISSN	1049-5398
EISSN	1532-2378
起始页码	5097
结束页码	5112
卷号	34 期号:9
英文摘要	As one of the most important livestock breeds on the Qinghai-Tibet Plateau, Tibetan sheep are of great importance to the local economy, agriculture and culture. Its adaptive mechanism in low temperature and low oxygen at highland altitudes has not been reported. In this study, transcriptome sequencing was used to analyze the heart, liver, spleen, lung, kidney, and muscle tissue of sheep at low and highland altitudes. LOC101112291, SELENOW, COL3A1, GPX1, TMSB4X and HSF4 were selected as candidate genes for adapting to plateau characteristics in Tibet Sheep. Besides, glutathione metabolism, arachidonic acid metabolism, nucleotide excision repair, regulation of actin cytoskeleton, protein digestion and absorption, thyroid hormone synthesis, relaxation signaling pathways may play important roles in the adaptation to plateau hypoxia, and cold tolerance. Structural analysis also showed that sequencing genes related to the adaptation mechanism of Tibet sheep to highland altitude. This study will lay a certain foundation for Tibet sheep research. Tibet sheep are an ancient species in the Qinghai Tibet Plateau. After a long period of domestication. Tibet sheep adapt to the hypoxic environment of the plateau in terms of physiology and morphology. At the same time, Tibet sheep is also one of the major sources of material for herdsmen in tibetan. In this study, six different tissue samples (heart, liver, spleen, lung, kidney, and muscle) of Tibet sheep were analyzed to reveal the underlying mechanisms of different tissues respond to hypothermia condition. The results showed that six key genes and eight important signaling pathways involved in regulating the adaptation of Tibet sheep to the plateau. In addition, there were more alternative splicing (AS) events and single nucleotide polymorphism (SNP) sites in highland altitude Tibet sheep than in lowland altitude sheep, which was also a concern in the highland altitude adaptability of Tibet sheep.
关键词	Tibet sheep hypoxia adaptation cold resistance high UV transcriptome
英文关键词	BROWN ADIPOSE-TISSUE; SPLICE VARIANTS; TRANSITION BIAS; EXPRESSION; HYPOXIA; MUSCLE; DNA; GLUTATHIONE; PULMONARY; RADIATION
WOS研究方向	Agriculture, Dairy & Animal Science ; Biotechnology & Applied Microbiology
WOS记录号	WOS:001067417700001
来源期刊	ANIMAL BIOTECHNOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282564
作者单位	Mianyang Teachers' College; Southwest Minzu University; Southwest Minzu University; Southwest University of Science & Technology - China
推荐引用方式 GB/T 7714	An, Li,Li, Yanyan,Yaq, Lin,et al. Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment[J],2023,34(9).
APA	An, Li.,Li, Yanyan.,Yaq, Lin.,Wang, Yong.,Dai, Qilin.,...&Wang, Jinling.(2023).Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment.ANIMAL BIOTECHNOLOGY,34(9).
MLA	An, Li,et al."Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment".ANIMAL BIOTECHNOLOGY 34.9(2023).