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DOI	10.1080/07388551.2022.2153008
	Metabolic engineering of Saccharomyces cerevisiae for the synthesis of valuable chemicals
	Wang, Shuai; Zhao, Fengguang; Yang, Manli; Lin, Ying; Han, Shuangyan
发表日期	2023
ISSN	0738-8551
EISSN	1549-7801
英文摘要	In the twenty first century, biotechnology offers great opportunities and solutions to climate change mitigation, energy and food security and resource efficiency. The use of metabolic engineering to modify microorganisms for producing industrially significant chemicals is developing and becoming a trend. As a famous, generally recognized as a safe (GRAS) model microorganism, Saccharomyces cerevisiae is widely used due to its excellent operational convenience and high fermentation efficiency. This review summarizes recent advancements in the field of using metabolic engineering strategies to construct engineered S. cerevisiae over the past ten years. Five different types of compounds are classified by their metabolites, and the modified metabolic pathways and strategies are summarized and discussed independently. This review may provide guidance for future metabolic engineering efforts toward such compounds and analogues. Additionally, the limitations of S. cerevisiae as a cell factory and its future trends are comprehensively discussed.
英文关键词	Saccharomyces cerevisiae; metabolic engineering; cell factory; chemicals; metabolic pathways; metabolic strategies
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000906696200001
来源期刊	CRITICAL REVIEWS IN BIOTECHNOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/281370
作者单位	South China University of Technology; South China University of Technology
推荐引用方式 GB/T 7714	Wang, Shuai,Zhao, Fengguang,Yang, Manli,et al. Metabolic engineering of Saccharomyces cerevisiae for the synthesis of valuable chemicals[J],2023.
APA	Wang, Shuai,Zhao, Fengguang,Yang, Manli,Lin, Ying,&Han, Shuangyan.(2023).Metabolic engineering of Saccharomyces cerevisiae for the synthesis of valuable chemicals.CRITICAL REVIEWS IN BIOTECHNOLOGY.
MLA	Wang, Shuai,et al."Metabolic engineering of Saccharomyces cerevisiae for the synthesis of valuable chemicals".CRITICAL REVIEWS IN BIOTECHNOLOGY (2023).