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DOI10.1038/s41588-023-01302-4
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
Yan, Haidong; Sun, Min; Zhang, Zhongren; Jin, Yarong; Zhang, Ailing; Lin, Chuang; Wu, Bingchao; He, Min; Xu, Bin; Wang, Jing; Qin, Peng; Mendieta, John Pablo; Nie, Gang; Wang, Jianping; Jones, Chris S. S.; Feng, Guangyan; Srivastava, Rakesh K. K.; Zhang, Xinquan; Bombarely, Aureliano; Luo, Dan; Jin, Long; Peng, Yuanying; Wang, Xiaoshan; Ji, Yang; Tian, Shilin; Huang, Linkai
Date Issued2023
ISSN1061-4036
EISSN1546-1718
startpage507
endpage+
Volume55Issue:3
Other AbstractPearl millet is an important cereal crop worldwide and shows superior heat tolerance. Here, we developed a graph-based pan-genome by assembling ten chromosomal genomes with one existing assembly adapted to different climates worldwide and captured 424,085 genomic structural variations (SVs). Comparative genomics and transcriptomics analyses revealed the expansion of the RWP-RK transcription factor family and the involvement of endoplasmic reticulum (ER)-related genes in heat tolerance. The overexpression of one RWP-RK gene led to enhanced plant heat tolerance and transactivated ER-related genes quickly, supporting the important roles of RWP-RK transcription factors and ER system in heat tolerance. Furthermore, we found that some SVs affected the gene expression associated with heat tolerance and SVs surrounding ER-related genes shaped adaptation to heat tolerance during domestication in the population. Our study provides a comprehensive genomic resource revealing insights into heat tolerance and laying a foundation for generating more robust crops under the changing climate. A graph-based pan-genome constructed using de novo genome assemblies of ten pearl millet accessions adapted to different climates worldwide identifies structural variations and their contribution to heat tolerance in pearl millet.
Language英语
WOS Research AreaGenetics & Heredity
WOS SubjectScience Citation Index Expanded (SCI-EXPANDED)
WOS IDWOS:000971784400002
journalNATURE GENETICS
Document Type期刊论文
Identifierhttp://gcip.llas.ac.cn/handle/2XKMVOVA/281256
AffiliationSichuan Agricultural University; Virginia Polytechnic Institute & State University; University System of Georgia; University of Georgia; Sichuan Agricultural University; Nanjing Agricultural University; Sichuan University; Sichuan Agricultural University; State University System of Florida; University of Florida; CGIAR; International Livestock Research Institute (ILRI); CGIAR; International Crops Research Institute for the Semi-Arid-Tropics (ICRISAT); Consejo Superior de Investigaciones Cientificas (CSIC); Sichuan Agricultural University; Sichuan Agricultural University; Sichuan Academy of Agricultural Sciences (SAAS); Wuhan University
Recommended Citation
GB/T 7714
Yan, Haidong,Sun, Min,Zhang, Zhongren,et al. Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet[J],2023,55(3).
APA Yan, Haidong.,Sun, Min.,Zhang, Zhongren.,Jin, Yarong.,Zhang, Ailing.,...&Huang, Linkai.(2023).Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet.NATURE GENETICS,55(3).
MLA Yan, Haidong,et al."Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet".NATURE GENETICS 55.3(2023).
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