气候变化领域集成服务门户(CCPortal): Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development

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DOI	10.3390/molecules27010313
	Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development
	Yeshi, Karma; Crayn, Darren; Ritmejeryte, Edita; Wangchuk, Phurpa
发表日期	2022
EISSN	1420-3049
卷号	27 期号:1
英文摘要	Plant secondary metabolites (PSMs) are vital for human health and constitute the skeletal framework of many pharmaceutical drugs. Indeed, more than 25% of the existing drugs belong to PSMs. One of the continuing challenges for drug discovery and pharmaceutical industries is gaining access to natural products, including medicinal plants. This bottleneck is heightened for endangered species prohibited for large sample collection, even if they show biological hits. While cultivating the pharmaceutically interesting plant species may be a solution, it is not always possible to grow the organism outside its natural habitat. Plants affected by abiotic stress present a potential alternative source for drug discovery. In order to overcome abiotic environmental stressors, plants may mount a defense response by producing a diversity of PSMs to avoid cells and tissue damage. Plants either synthesize new chemicals or increase the concentration (in most instances) of existing chemicals, including the prominent bioactive lead compounds morphine, camptothecin, catharanthine, epicatechin-3-gallate (EGCG), quercetin, resveratrol, and kaempferol. Most PSMs produced under various abiotic stress conditions are plant defense chemicals and are functionally anti-inflammatory and antioxidative. The major PSM groups are terpenoids, followed by alkaloids and phenolic compounds. We have searched the literature on plants affected by abiotic stress (primarily studied in the simulated growth conditions) and their PSMs (including pharmacological activities) from PubMed, Scopus, MEDLINE Ovid, Google Scholar, Databases, and journal websites. We used search keywords: stress-affected plants, plant secondary metabolites, abiotic stress, climatic influence, pharmacological activities, bioactive compounds, drug discovery, and medicinal plants and retrieved published literature between 1973 to 2021. This review provides an overview of variation in bioactive phytochemical production in plants under various abiotic stress and their potential in the biodiscovery of therapeutic drugs. We excluded studies on the effects of biotic stress on PSMs.
英文关键词	secondary metabolites; climate change; drug discovery; abiotic stress
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000741135500001
来源期刊	MOLECULES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/281087
作者单位	James Cook University; James Cook University
推荐引用方式 GB/T 7714	Yeshi, Karma,Crayn, Darren,Ritmejeryte, Edita,et al. Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development[J],2022,27(1).
APA	Yeshi, Karma,Crayn, Darren,Ritmejeryte, Edita,&Wangchuk, Phurpa.(2022).Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development.MOLECULES,27(1).
MLA	Yeshi, Karma,et al."Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development".MOLECULES 27.1(2022).