气候变化领域集成服务门户(CCPortal): A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development

CCPortal

DOI	10.3390/v14050969
	A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development
	Vasconcelos de Lima Cavalcanti, Thaise Yasmine; Pereira, Mylena Ribeiro; de Paula, Sergio Oliveira; de Oliveira Franca, Rafael Freitas
发表日期	2022
EISSN	1999-4915
卷号	14 期号:5
英文摘要	Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain-Barre Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates.
英文关键词	chikungunya; pathogenesis; virus receptor; vaccine; immunopathogenesis; epidemiology
语种	英语
WOS研究方向	Virology
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000801684700001
来源期刊	VIRUSES-BASEL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/280995
作者单位	Fundacao Oswaldo Cruz; Universidade Federal Rural de Pernambuco (UFRPE); Universidade Federal de Vicosa
推荐引用方式 GB/T 7714	Vasconcelos de Lima Cavalcanti, Thaise Yasmine,Pereira, Mylena Ribeiro,de Paula, Sergio Oliveira,et al. A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development[J],2022,14(5).
APA	Vasconcelos de Lima Cavalcanti, Thaise Yasmine,Pereira, Mylena Ribeiro,de Paula, Sergio Oliveira,&de Oliveira Franca, Rafael Freitas.(2022).A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development.VIRUSES-BASEL,14(5).
MLA	Vasconcelos de Lima Cavalcanti, Thaise Yasmine,et al."A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development".VIRUSES-BASEL 14.5(2022).