气候变化领域集成服务门户(CCPortal): Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease

CCPortal

DOI	10.1111/all.15240
	Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease
	Sozener, Zeynep Celebi; Ozturk, Betul Ozdel; Cerci, Pamir; Turk, Murat; Akin, Begum Gorgulu; Akdis, Mubeccel; Altiner, Seda; Ozbey, Umus; Ogulur, Ismail; Mitamura, Yasutaka; Yilmaz, Insu; Nadeau, Kari; Ozdemir, Cevdet; Mungan, Dilsad; Akdis, Cezmi A.
发表日期	2022
ISSN	0105-4538
EISSN	1398-9995
起始页码	1418
结束页码	1449
卷号	77 期号:5
英文摘要	Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, and asthma. The epithelial barrier hypothesis provides a mechanistic explanation of how these factors can explain the rapid increase in allergic and autoimmune diseases. In this review, we discuss factors affecting the planet's health in the context of the 'epithelial barrier hypothesis,' including climate change, pollution, changes and loss of biodiversity, and emphasize the changes in the external exposome in the last few decades and their effects on allergic diseases. In addition, the roles of increased dietary fatty acid consumption and environmental substances (detergents, airborne pollen, ozone, microplastics, nanoparticles, and tobacco) affecting epithelial barriers are discussed. Considering the emerging data from recent studies, we suggest stringent governmental regulations, global policy adjustments, patient education, and the establishment of individualized control measures to mitigate environmental threats and decrease allergic disease.
英文关键词	air pollution; climate change; epithelial barrier; exposome; nutrition
语种	英语
WOS研究方向	Allergy ; Immunology
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000755601200001
来源期刊	ALLERGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/280496
作者单位	City Hospital Ankara; Ankara University; University of Zurich; Swiss Institute of Allergy & Asthma Research; Kahramanmaras Necip Fazil City Hospital; Ankara University; Erciyes University; Stanford University; Istanbul University; Istanbul University
推荐引用方式 GB/T 7714	Sozener, Zeynep Celebi,Ozturk, Betul Ozdel,Cerci, Pamir,et al. Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease[J],2022,77(5).
APA	Sozener, Zeynep Celebi.,Ozturk, Betul Ozdel.,Cerci, Pamir.,Turk, Murat.,Akin, Begum Gorgulu.,...&Akdis, Cezmi A..(2022).Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease.ALLERGY,77(5).
MLA	Sozener, Zeynep Celebi,et al."Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease".ALLERGY 77.5(2022).