气候变化领域集成服务门户(CCPortal): The rate and potential relevance of new mutations in a colonizing plant lineage

CCPortal

DOI	10.1371/journal.pgen.1007155
	The rate and potential relevance of new mutations in a colonizing plant lineage
	Exposito-Alonso, Moises; Becker, Claude; Schuenemann, Verena J.; Reiter, Ella; Setzer, Claudia; Slovak, Radka; Brachi, Benjamin; Hagmann, Joerg; Grimm, Dominik G.; Chen, Jiahui; Busch, Wolfgang; Bergelson, Joy; Ness, Rob W.; Krause, Johannes; Burbano, Hernan A.; Weigel, Detlef
通讯作者	Weigel, D (通讯作者)
发表日期	2018
ISSN	1553-7404
卷号	14 期号:2
英文摘要	By following the evolution of populations that are initially genetically homogeneous, much can be learned about core biological principles. For example, it allows for detailed studies of the rate of emergence of de novo mutations and their change in frequency due to drift and selection. Unfortunately, in multicellular organisms with generation times of months or years, it is difficult to set up and carry out such experiments over many generations. An alternative is provided by natural evolution experiments that started from colonizations or invasions of new habitats by selfing lineages. With limited or missing gene flow from other lineages, new mutations and their effects can be easily detected. North America has been colonized in historic times by the plant Arabidopsis thaliana, and although multiple inter-crossing lineages are found today, many of the individuals belong to a single lineage, HPG1. To determine in this lineage the rate of substitutions-the subset of mutations that survived natural selection and drift-, we have sequenced genomes from plants collected between 1863 and 2006. We identified 73 modern and 27 herbarium specimens that belonged to HPG1. Using the estimated substitution rate, we infer that the last common HPG1 ancestor lived in the early 17 th century, when it was most likely introduced by chance from Europe. Mutations in coding regions are depleted in frequency compared to those in other portions of the genome, consistent with purifying selection. Nevertheless, a handful of mutations is found at high frequency in present-day populations. We link these to detectable phenotypic variance in traits of known ecological importance, life history and growth, which could reflect their adaptive value. Our work showcases how, by applying genomics methods to a combination of modern and historic samples from colonizing lineages, we can directly study new mutations and their potential evolutionary relevance.
关键词	RESPONSIVE GENE-EXPRESSION ARABIDOPSIS-THALIANA TRANSCRIPTIONAL REGULATOR POPULATION-GENETICS EVOLUTIONARY RATES R-PACKAGE ADAPTATION MITOCHONDRIAL ACCUMULATION MULTIVARIATE
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000426361900006
来源期刊	PLOS GENETICS
来源机构	中国科学院青藏高原研究所
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/259382
推荐引用方式 GB/T 7714	Exposito-Alonso, Moises,Becker, Claude,Schuenemann, Verena J.,et al. The rate and potential relevance of new mutations in a colonizing plant lineage[J]. 中国科学院青藏高原研究所,2018,14(2).
APA	Exposito-Alonso, Moises.,Becker, Claude.,Schuenemann, Verena J..,Reiter, Ella.,Setzer, Claudia.,...&Weigel, Detlef.(2018).The rate and potential relevance of new mutations in a colonizing plant lineage.PLOS GENETICS,14(2).
MLA	Exposito-Alonso, Moises,et al."The rate and potential relevance of new mutations in a colonizing plant lineage".PLOS GENETICS 14.2(2018).