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DOI	10.1016/j.jep.2014.10.014
	Traditional uses of medicinal plants in gastrointestinal disorders in Nepal
	Rokaya, Maan B.; Uprety, Yadav; Poudel, Ram C.; Timsina, Binu; Muenzbergova, Zuzana; Asselin, Hugo; Tiwari, Achyut; Shrestha, Shyam S.; Sigdel, Shalik R.
通讯作者	Rokaya, MB (通讯作者)
发表日期	2014
ISSN	0378-8741
EISSN	1872-7573
起始页码	221
结束页码	229
卷号	158
英文摘要	Ethnopharmacological relevance: Gastrointestinal disorders cause morbidity and can lead to mortality, especially in the developing world where sanitation is deficient. A large part of the human population relies on medicinal plants for treating various diseases, including gastrointestinal disorders. The present review summarizes the traditional uses of medicinal plants of Nepal used to treat gastrointestinal disorders, and evaluates their bio-efficacy based on a review of the available phytochemical and pharmacological literature. Material and methods: We searched different electronic databases and libraries for the literature on medicinal plants used in Nepal to treat gastrointestinal disorders. For each species, we also searched the literature for information on conservation status, as well as for phytochemical and pharmacological studies in support of the ethnobotanical information. We used principal component analysis to explore the relation among disorders and plant families, plant life forms, plant parts and preparation modes. We also performed permutation tests to determine if botanical families were used more often than expected considering their availability in the Nepali flora. Results: We documented a total of 947 species belonging to 158 families and 586 genera used to treat gastrointestinal disorders in Nepal. Diarrhea was the disorder treated by the highest number of species (348), followed by stomachache (340) and dysentery (307). Among the reported species, five were endemic to Nepal, whereas 16 orchid species were protected under CITES Appendices II and III. The randomization test showed that species belonging to 14 families were used less often than expected, whereas plants belonging to 25 families were used more often than expected. The PCA scatter plot showed distinct groups of gastrointestinal disorders treated with similar plant life forms, plant parts, and/or preparation modes. We found 763 phytochemical studies on 324 species and 654 pharmacological studies on 269 species. Conclusion: We showed the diversity and importance of medicinal plants used to treat gastrointestinal disorders in the traditional health care system of Nepal. As such disorders are still causing several deaths each year, it is of the utmost importance to conduct phytochemical and pharmacological studies on the most promising species. It is also crucial to increase access to traditional medicine, especially in rural areas. Threatened species need special attention for traditional herbal medicine to be exploited sustainably. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	LIMPOPO PROVINCE RASUWA DISTRICT CHOLERA KNOWLEDGE PRODUCTS PATTERNS PHYTOCHEMISTRY CONSERVATION ETHNOBOTANY DIVERSITY
英文关键词	Medicinal plants; Principal component analysis; Randomization test; Ethnomedicine; Drug development
语种	英语
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000348084600020
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
来源机构	中国科学院青藏高原研究所
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/258404
推荐引用方式 GB/T 7714	Rokaya, Maan B.,Uprety, Yadav,Poudel, Ram C.,et al. Traditional uses of medicinal plants in gastrointestinal disorders in Nepal[J]. 中国科学院青藏高原研究所,2014,158.
APA	Rokaya, Maan B..,Uprety, Yadav.,Poudel, Ram C..,Timsina, Binu.,Muenzbergova, Zuzana.,...&Sigdel, Shalik R..(2014).Traditional uses of medicinal plants in gastrointestinal disorders in Nepal.JOURNAL OF ETHNOPHARMACOLOGY,158.
MLA	Rokaya, Maan B.,et al."Traditional uses of medicinal plants in gastrointestinal disorders in Nepal".JOURNAL OF ETHNOPHARMACOLOGY 158(2014).