气候变化领域集成服务门户(CCPortal): Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation

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DOI	10.1038/s41559-022-01709-y
	Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation
	McLeod D.V.; Gandon S.
发表日期	2022
ISSN	2397-334X
英文摘要	Pathogen adaptation to public health interventions such as vaccination may take tortuous routes and involve multiple mutations at different locations in the pathogen genome, acting on distinct phenotypic traits. Yet how these multi-locus adaptations jointly evolve is poorly understood. Here we consider the joint evolution of two adaptations: pathogen escape from the vaccine-induced immune response and adjustments to pathogen virulence affecting transmission or clearance. We elucidate the role played by epistasis and recombination, with an emphasis on the different protective effects of vaccination. We show that vaccines blocking infection, reducing transmission and/or increasing clearance generate positive epistasis between the vaccine-escape and virulence alleles, favouring strains that carry both mutations, whereas vaccines reducing virulence mortality generate negative epistasis, favouring strains that carry either mutation but not both. High rates of recombination can affect these predictions. If epistasis is positive, frequent recombination can prevent the transient build-up of more virulent escape strains. If epistasis is negative, frequent recombination between loci can create an evolutionary bistability, favouring whichever adaptation is more accessible. Our work provides a timely alternative to the variant-centred perspective on pathogen adaptation and captures the effect of different types of vaccine on the interference between multiple adaptive mutations. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257200
作者单位	CEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France; Institute of Ecology and Evolution, Universit?t Bern, Bern, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
推荐引用方式 GB/T 7714	McLeod D.V.,Gandon S.. Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation[J],2022.
APA	McLeod D.V.,&Gandon S..(2022).Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation.Nature Ecology & Evolution.
MLA	McLeod D.V.,et al."Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation".Nature Ecology & Evolution (2022).