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DOI	10.1038/s41559-022-01730-1
	Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast
	Farkas Z.; Kovács K.; Sarkadi Z.; Kalapis D.; Fekete G.; Birtyik F.; Ayaydin F.; Molnár C.; Horváth P.; Pál C.; Papp B.
发表日期	2022
ISSN	2397-334X
英文摘要	Deleterious mutations are generally considered to be irrelevant for morphological evolution. However, they could be compensated by conditionally beneficial mutations, thereby providing access to new adaptive paths. Here we use high-dimensional phenotyping of laboratory-evolved budding yeast lineages to demonstrate that new cellular morphologies emerge exceptionally rapidly as a by-product of gene loss and subsequent compensatory evolution. Unexpectedly, the capacities for invasive growth, multicellular aggregation and biofilm formation also spontaneously evolve in response to gene loss. These multicellular phenotypes can be achieved by diverse mutational routes and without reactivating the canonical regulatory pathways. These ecologically and clinically relevant traits originate as pleiotropic side effects of compensatory evolution and have no obvious utility in the laboratory environment. The extent of morphological diversity in the evolved lineages is comparable to that of natural yeast isolates with diverse genetic backgrounds and lifestyles. Finally, we show that both the initial gene loss and subsequent compensatory mutations contribute to new morphologies, with their synergistic effects underlying specific morphological changes. We conclude that compensatory evolution is a previously unrecognized source of morphological diversity and phenotypic novelties. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257192
作者单位	Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, E?tv?s Loránd Research Network, Szeged, Hungary; HCEMM-BRC Metabolic Systems Biology Lab, Szeged, Hungary; Doctoral School of Multidisciplinary Medical Science, University of Szeged, Szeged, Hungary; Functional Cell Biology and Immunology Advanced Core Facility (FCBI), Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Szeged, Hungary; Faculty of Medicine, Albert Szent-Gy?rgyi Health Centre, Interdisciplinary R&D and Innovation Centre of Excellence, University of Szeged, Szeged, Hungary; Laboratory of Cellular Imaging, Biological Research Centre, E?tv?s Loránd Research Network, Szeged, Hungary; Broad Institute of MIT and Harvard, Cambridge, MA, United States; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Single-Cell Technologies Ltd., Szeged, Hungary
推荐引用方式 GB/T 7714	Farkas Z.,Kovács K.,Sarkadi Z.,et al. Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast[J],2022.
APA	Farkas Z..,Kovács K..,Sarkadi Z..,Kalapis D..,Fekete G..,...&Papp B..(2022).Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast.Nature Ecology & Evolution.
MLA	Farkas Z.,et al."Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast".Nature Ecology & Evolution (2022).