气候变化领域集成服务门户(CCPortal): Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs

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DOI	10.1038/s41559-022-01768-1
	Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs
	Luján A.M.; Paterson S.; Hesse E.; Sommer L.M.; Marvig R.L.; Sharma M.D.; Alseth E.O.; Ciofu O.; Smania A.M.; Molin S.; Johansen H.K.; Buckling A.
发表日期	2022
ISSN	2397-334X
英文摘要	Bacteria with increased mutation rates (mutators) are common in chronic infections and are associated with poorer clinical outcomes, especially in the case of Pseudomonas aeruginosa infecting cystic fibrosis (CF) patients. There is, however, considerable between-patient variation in both P. aeruginosa mutator frequency and the composition of co-infecting pathogen communities. We investigated whether community context might affect selection of mutators. Using an in vitro CF model community, we show that P. aeruginosa mutators were favoured in the absence of other species but not in their presence. This was because there were trade-offs between adaptation to the biotic and abiotic environments (for example, loss of quorum sensing and associated toxin production was beneficial in the latter but not the former in our in vitro model community) limiting the evolvability advantage of an elevated mutation rate. Consistent with a role of co-infecting pathogens selecting against P. aeruginosa mutators in vivo, we show that the mutation frequency of P. aeruginosa population was negatively correlated with the frequency and diversity of co-infecting bacteria in CF infections. Our results suggest that co-infecting taxa can select against P. aeruginosa mutators, which may have potentially beneficial clinical consequences. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257164
作者单位	ESI and CEC, Biosciences, University of Exeter, Penryn, United Kingdom; Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba, CONICET, Córdoba, Argentina; Instituto de Investigaciones en Recursos Naturales y Sustentabilidad Jose Sanchez Labrador S.J., IRNASUS-CONICET, Córdoba, Argentina; Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark; Center for Genomic Medicine, Rigshopitalet, Copenhagen, Denmark; Costerton Biofilm Center, Department for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
推荐引用方式 GB/T 7714	Luján A.M.,Paterson S.,Hesse E.,et al. Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs[J],2022.
APA	Luján A.M..,Paterson S..,Hesse E..,Sommer L.M..,Marvig R.L..,...&Buckling A..(2022).Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs.Nature Ecology & Evolution.
MLA	Luján A.M.,et al."Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs".Nature Ecology & Evolution (2022).