气候变化领域集成服务门户(CCPortal): Synchrony and idiosyncrasy in the gut microbiome of wild baboons

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DOI	10.1038/s41559-022-01773-4
	Synchrony and idiosyncrasy in the gut microbiome of wild baboons
	Bj?rk J.R.; Dasari M.R.; Roche K.; Grieneisen L.; Gould T.J.; Grenier J.-C.; Yotova V.; Gottel N.; Jansen D.; Gesquiere L.R.; Gordon J.B.; Learn N.H.; Wango T.L.; Mututua R.S.; Kinyua Warutere J.; Siodi L.; Mukherjee S.; Barreiro L.B.; Alberts S.C.; Gilbert J.A.; Tung J.; Blekhman R.; Archie E.A.
发表日期	2022
ISSN	2397-334X
英文摘要	Human gut microbial dynamics are highly individualized, making it challenging to link microbiota to health and to design universal microbiome therapies. This individuality is typically attributed to variation in host genetics, diets, environments and medications but it could also emerge from fundamental ecological forces that shape microbiota more generally. Here, we leverage extensive gut microbial time series from wild baboons—hosts who experience little interindividual dietary and environmental heterogeneity—to test whether gut microbial dynamics are synchronized across hosts or largely idiosyncratic. Despite their shared lifestyles, baboon microbiota were only weakly synchronized. The strongest synchrony occurred among baboons living in the same social group, probably because group members range over the same habitat and simultaneously encounter the same sources of food and water. However, this synchrony was modest compared to each host’s personalized dynamics. In support, host-specific factors, especially host identity, explained, on average, more than three times the deviance in longitudinal dynamics compared to factors shared with social group members and ten times the deviance of factors shared across the host population. These results contribute to mounting evidence that highly idiosyncratic gut microbiomes are not an artefact of modern human environments and that synchronizing forces in the gut microbiome (for example, shared environments, diets and microbial dispersal) are not strong enough to overwhelm key drivers of microbiome personalization, such as host genetics, priority effects, horizontal gene transfer and functional redundancy. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257159
作者单位	Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, United States; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, United States; Department of Genetics, CHU Sainte Justine Research Center, Montréal, QC, Canada; Research Center, Montreal Heart Institute, Montréal, QC, Canada; Department of Pediatrics and the Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, United States; Department of Biology, Duke University, Durham, NC, United States; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Amboseli Baboon Research Project, Amboseli National Park, Amboseli, Kenya; The Department of Veterinary Anatomy and Animal Physiology, University of Nairobi, Nairobi, Kenya; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, Unite...
推荐引用方式 GB/T 7714	Bj?rk J.R.,Dasari M.R.,Roche K.,et al. Synchrony and idiosyncrasy in the gut microbiome of wild baboons[J],2022.
APA	Bj?rk J.R..,Dasari M.R..,Roche K..,Grieneisen L..,Gould T.J..,...&Archie E.A..(2022).Synchrony and idiosyncrasy in the gut microbiome of wild baboons.Nature Ecology & Evolution.
MLA	Bj?rk J.R.,et al."Synchrony and idiosyncrasy in the gut microbiome of wild baboons".Nature Ecology & Evolution (2022).