气候变化领域集成服务门户(CCPortal): Spatial structure governs the mode of tumour evolution

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DOI	10.1038/s41559-021-01615-9
	Spatial structure governs the mode of tumour evolution
	Noble R.; Burri D.; Le Sueur C.; Lemant J.; Viossat Y.; Kather J.N.; Beerenwinkel N.
发表日期	2022
ISSN	2397-334X
起始页码	207
结束页码	217
卷号	6 期号:2
英文摘要	Characterizing the mode—the way, manner or pattern—of evolution in tumours is important for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred various modes, including branching, punctuated and neutral evolution, but it is unclear why a particular pattern predominates in any given tumour. Here we propose that tumour architecture is key to explaining the variety of observed genetic patterns. We examine this hypothesis using spatially explicit population genetics models and demonstrate that, within biologically relevant parameter ranges, different spatial structures can generate four tumour evolutionary modes: rapid clonal expansion, progressive diversification, branching evolution and effectively almost neutral evolution. Quantitative indices for describing and classifying these evolutionary modes are presented. Using these indices, we show that our model predictions are consistent with empirical observations for cancer types with corresponding spatial structures. The manner of cell dispersal and the range of cell–cell interactions are found to be essential factors in accurately characterizing, forecasting and controlling tumour evolution. ? 2021, The Author(s).
语种	英语
scopus关键词	genetics; human; neoplasm; Humans; Neoplasms
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257150
作者单位	Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland; Biozentrum, University of Basel, Basel, Switzerland; Ceremade, Université Paris Dauphine-PSL, Paris, France; German Cancer Consortium (DKTK), Heidelberg, Germany; Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany; Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany; Department of Mathematics, City, University of London, London, United Kingdom
推荐引用方式 GB/T 7714	Noble R.,Burri D.,Le Sueur C.,et al. Spatial structure governs the mode of tumour evolution[J],2022,6(2).
APA	Noble R..,Burri D..,Le Sueur C..,Lemant J..,Viossat Y..,...&Beerenwinkel N..(2022).Spatial structure governs the mode of tumour evolution.Nature Ecology & Evolution,6(2).
MLA	Noble R.,et al."Spatial structure governs the mode of tumour evolution".Nature Ecology & Evolution 6.2(2022).