气候变化领域集成服务门户(CCPortal): Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans

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DOI	10.1038/s41559-021-01614-w
	Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans
	Zhang D.; Leng L.; Chen C.; Huang J.; Zhang Y.; Yuan H.; Ma C.; Chen H.; Zhang Y.E.
发表日期	2022
ISSN	2397-334X
起始页码	273
结束页码	287
卷号	6 期号:3
英文摘要	Despite polymorphic duplicate genes' importance for the early stages of duplicate gene evolution, they are less studied than old gene duplicates. Two essential questions thus remain poorly addressed: how does dosage sensitivity, imposed by stoichiometry in protein complexes or by X chromosome dosage compensation, affect the emergence of complete duplicate genes? Do introns facilitate intergenic and intragenic chimaerism as predicted by the theory of exon shuffling? Here, we analysed new data for Drosophila and public data for humans, to characterize polymorphic duplicate genes with respect to dosage, exon–intron structures and allele frequencies. We found that complete duplicate genes are under dosage constraint induced by protein stoichiometry but potentially tolerated by X chromosome dosage compensation. We also found that in the intron-rich human genome, gene fusions and intragenic duplications extensively use intronic breakpoints generating in-frame proteins, in accordance with the theory of exon shuffling. Finally, we found that only a small proportion of complete or partial duplicates are at high frequencies, indicating the deleterious nature of dosage or gene structural changes. Altogether, we demonstrate how mechanistic factors including dosage sensitivity and exon–intron structure shape the short-term functional consequences of gene duplication. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	animal; Drosophila; duplicate gene; exon; gene duplication; genetics; human; intron; Animals; Drosophila; Exons; Gene Duplication; Genes, Duplicate; Humans; Introns
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257132
作者单位	Key Laboratory of Zoological Systematics and Evolution & State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China; China National Center for Bioinformation, Beijing, China; Chinese Institute for Brain Research, Beijing, China; School of Ecology and Environment, Northwestern Polytechnical University, Xi’an, China
推荐引用方式 GB/T 7714	Zhang D.,Leng L.,Chen C.,et al. Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans[J],2022,6(3).
APA	Zhang D..,Leng L..,Chen C..,Huang J..,Zhang Y..,...&Zhang Y.E..(2022).Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans.Nature Ecology & Evolution,6(3).
MLA	Zhang D.,et al."Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans".Nature Ecology & Evolution 6.3(2022).