气候变化领域集成服务门户(CCPortal): Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria

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DOI	10.1038/s41559-021-01638-2
	Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria
	Mu?oz-Gómez S.A.; Susko E.; Williamson K.; Eme L.; Slamovits C.H.; Moreira D.; López-García P.; Roger A.J.
发表日期	2022
ISSN	2397-334X
起始页码	253
结束页码	262
卷号	6 期号:3
英文摘要	Determining the phylogenetic origin of mitochondria is key to understanding the ancestral mitochondrial symbiosis and its role in eukaryogenesis. However, the precise evolutionary relationship between mitochondria and their closest bacterial relatives remains hotly debated. The reasons include pervasive phylogenetic artefacts as well as limited protein and taxon sampling. Here we developed a new model of protein evolution that accommodates both across-site and across-branch compositional heterogeneity. We applied this site-and-branch-heterogeneous model (MAM60 + GFmix) to a considerably expanded dataset that comprises 108 mitochondrial proteins of alphaproteobacterial origin, and novel metagenome-assembled genomes from microbial mats, microbialites and sediments. The MAM60 + GFmix model fits the data much better and agrees with analyses of compositionally homogenized datasets with conventional site-heterogenous models. The consilience of evidence thus suggests that mitochondria are sister to the Alphaproteobacteria to the exclusion of MarineProteo1 and Magnetococcia. We also show that the ancestral presence of the crista-developing mitochondrial contact site and cristae organizing system (a mitofilin-domain-containing Mic60 protein) in mitochondria and the Alphaproteobacteria only supports their close relationship. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	mitochondrial protein; Alphaproteobacteria; genetics; metabolism; metagenome; mitochondrion; phylogeny; Alphaproteobacteria; Metagenome; Mitochondria; Mitochondrial Proteins; Phylogeny
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257126
作者单位	Ecologie Systématique Evolution, CNRS, Université Paris-Saclay, AgroParisTech, Orsay, France; Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, Canada; Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
推荐引用方式 GB/T 7714	Mu?oz-Gómez S.A.,Susko E.,Williamson K.,et al. Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria[J],2022,6(3).
APA	Mu?oz-Gómez S.A..,Susko E..,Williamson K..,Eme L..,Slamovits C.H..,...&Roger A.J..(2022).Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria.Nature Ecology & Evolution,6(3).
MLA	Mu?oz-Gómez S.A.,et al."Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria".Nature Ecology & Evolution 6.3(2022).