气候变化领域集成服务门户(CCPortal): Supergene origin and maintenance in Atlantic cod

CCPortal

DOI	10.1038/s41559-022-01661-x
	Supergene origin and maintenance in Atlantic cod
	Matschiner M.; Barth J.M.I.; T?rresen O.K.; Star B.; Baalsrud H.T.; Brieuc M.S.O.; Pampoulie C.; Bradbury I.; Jakobsen K.S.; Jentoft S.
发表日期	2022
ISSN	2397-334X
起始页码	469
结束页码	481
卷号	6 期号:4
英文摘要	Supergenes are sets of genes that are inherited as a single marker and encode complex phenotypes through their joint action. They are identified in an increasing number of organisms, yet their origins and evolution remain enigmatic. In Atlantic cod, four megabase-scale supergenes have been identified and linked to migratory lifestyle and environmental adaptations. Here we investigate the origin and maintenance of these four supergenes through analysis of whole-genome-sequencing data, including a new long-read-based genome assembly for a non-migratory Atlantic cod individual. We corroborate the finding that chromosomal inversions underlie all four supergenes, and we show that they originated at different times between 0.40 and 1.66 million years ago. We reveal gene flux between supergene haplotypes where migratory and stationary Atlantic cod co-occur and conclude that this gene flux is driven by gene conversion, on the basis of an increase in GC content in exchanged sites. Additionally, we find evidence for double crossover between supergene haplotypes, leading to the exchange of an ~275 kilobase fragment with genes potentially involved in adaptation to low salinity in the Baltic Sea. Our results suggest that supergenes can be maintained over long timescales in the same way as hybridizing species, through the selective purging of introduced genetic variation. ? 2022, The Author(s).
语种	英语
scopus关键词	adaptation; animal; Atlantic cod; chromosome inversion; genetics; haplotype; single nucleotide polymorphism; Adaptation, Physiological; Animals; Chromosome Inversion; Gadus morhua; Haplotypes; Polymorphism, Single Nucleotide
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257109
作者单位	Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway; Department of Palaeontology and Museum, University of Zurich, Zurich, Switzerland; Zoological Institute, Department of Environmental Sciences, University of Basel, Basel, Switzerland; Marine and Freshwater Research Institute, Hafnarfj?rdur, Iceland; Fisheries and Oceans Canada, St John’s, Newfoundland and Labrador, Canada; Natural History Museum, University of Oslo, Oslo, Norway
推荐引用方式 GB/T 7714	Matschiner M.,Barth J.M.I.,T?rresen O.K.,et al. Supergene origin and maintenance in Atlantic cod[J],2022,6(4).
APA	Matschiner M..,Barth J.M.I..,T?rresen O.K..,Star B..,Baalsrud H.T..,...&Jentoft S..(2022).Supergene origin and maintenance in Atlantic cod.Nature Ecology & Evolution,6(4).
MLA	Matschiner M.,et al."Supergene origin and maintenance in Atlantic cod".Nature Ecology & Evolution 6.4(2022).