气候变化领域集成服务门户(CCPortal): Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

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DOI	10.1038/s41559-022-01669-3
	Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution
	Schenk M.F.; Zwart M.P.; Hwang S.; Ruelens P.; Severing E.; Krug J.; de Visser J.A.G.M.
发表日期	2022
ISSN	2397-334X
起始页码	439
结束页码	447
卷号	6 期号:4
英文摘要	Mutations with large fitness benefits and mutations occurring at high rates may both cause parallel evolution, but their contribution is predicted to depend on population size. Moreover, high-rate and large-benefit mutations may have different long-term adaptive consequences. We show that small and 100-fold larger bacterial populations evolve resistance to a β-lactam antibiotic by using similar numbers, but different types of mutations. Small populations frequently substitute similar high-rate structural variants and loss-of-function point mutations, including the deletion of a low-activity β-lactamase, and evolve modest resistance levels. Large populations more often use low-rate, large-benefit point mutations affecting the same targets, including mutations activating the β-lactamase and other gain-of-function mutations, leading to much higher resistance levels. Our results demonstrate the separation by clonal interference of mutation classes with divergent adaptive consequences, causing a shift from high-rate to large-benefit mutations with increases in population size. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	antiinfective agent; beta lactamase; bacterium; genetics; mutation; population density; Anti-Bacterial Agents; Bacteria; beta-Lactamases; Mutation; Population Density
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257099
作者单位	Laboratory of Genetics, Wageningen University and Research, Wageningen, Netherlands; Wageningen Food Safety Research, Wageningen, Netherlands; Institute for Biological Physics, University of Cologne, Cologne, Germany; Netherlands Institute of Ecology, Wageningen, Netherlands; Capital Fund Management, Paris, France; Max Planck Institute for Plant Breeding Research, Cologne, Germany
推荐引用方式 GB/T 7714	Schenk M.F.,Zwart M.P.,Hwang S.,et al. Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution[J],2022,6(4).
APA	Schenk M.F..,Zwart M.P..,Hwang S..,Ruelens P..,Severing E..,...&de Visser J.A.G.M..(2022).Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution.Nature Ecology & Evolution,6(4).
MLA	Schenk M.F.,et al."Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution".Nature Ecology & Evolution 6.4(2022).