气候变化领域集成服务门户(CCPortal): Hibernation slows epigenetic ageing in yellow-bellied marmots

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DOI	10.1038/s41559-022-01679-1
	Hibernation slows epigenetic ageing in yellow-bellied marmots
	Pinho G.M.; Martin J.G.A.; Farrell C.; Haghani A.; Zoller J.A.; Zhang J.; Snir S.; Pellegrini M.; Wayne R.K.; Blumstein D.T.; Horvath S.
发表日期	2022
ISSN	2397-334X
起始页码	418
结束页码	426
卷号	6 期号:4
英文摘要	Species that hibernate generally live longer than would be expected based solely on their body size. Hibernation is characterized by long periods of metabolic suppression (torpor) interspersed by short periods of increased metabolism (arousal). The torpor–arousal cycles occur multiple times during hibernation, and it has been suggested that processes controlling the transition between torpor and arousal states cause ageing suppression. Metabolic rate is also a known correlate of longevity; we thus proposed the ‘hibernation–ageing hypothesis’ whereby ageing is suspended during hibernation. We tested this hypothesis in a well-studied population of yellow-bellied marmots (Marmota flaviventer), which spend 7–8 months per year hibernating. We used two approaches to estimate epigenetic age: the epigenetic clock and the epigenetic pacemaker. Variation in epigenetic age of 149 samples collected throughout the life of 73 females was modelled using generalized additive mixed models (GAMM), where season (cyclic cubic spline) and chronological age (cubic spline) were fixed effects. As expected, the GAMM using epigenetic ages calculated from the epigenetic pacemaker was better able to detect nonlinear patterns in epigenetic ageing over time. We observed a logarithmic curve of epigenetic age with time, where the epigenetic age increased at a higher rate until females reached sexual maturity (two years old). With respect to circannual patterns, the epigenetic age increased during the active season and essentially stalled during the hibernation period. Taken together, our results are consistent with the hibernation–ageing hypothesis and may explain the enhanced longevity in hibernators. ? 2022, The Author(s).
语种	英语
scopus关键词	animal; female; genetic epigenesis; genetics; hibernation; longevity; Marmota; metabolism; season; Animals; Epigenesis, Genetic; Female; Hibernation; Longevity; Marmota; Seasons
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257097
作者单位	Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States; CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil; Department of Biology, University of Ottawa, Ottawa, ON, Canada; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, United States; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States; Department of Evolutionary & Environmental Biology, Institute of Evolution, University of Haifa, Haifa, Israel; Rocky Mountain Biological Laboratory, Crested Butte, CO, United States
推荐引用方式 GB/T 7714	Pinho G.M.,Martin J.G.A.,Farrell C.,et al. Hibernation slows epigenetic ageing in yellow-bellied marmots[J],2022,6(4).
APA	Pinho G.M..,Martin J.G.A..,Farrell C..,Haghani A..,Zoller J.A..,...&Horvath S..(2022).Hibernation slows epigenetic ageing in yellow-bellied marmots.Nature Ecology & Evolution,6(4).
MLA	Pinho G.M.,et al."Hibernation slows epigenetic ageing in yellow-bellied marmots".Nature Ecology & Evolution 6.4(2022).