气候变化领域集成服务门户(CCPortal): Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas

CCPortal

DOI	10.1038/s41559-022-01703-4
	Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas
	Chiou K.L.; Janiak M.C.; Schneider-Crease I.A.; Sen S.; Ayele F.; Chuma I.S.; Knauf S.; Lemma A.; Signore A.V.; D’Ippolito A.M.; Abebe B.; Haile A.A.; Kebede F.; Fashing P.J.; Nguyen N.; McCann C.; Houck M.L.; Wall J.D.; Burrell A.S.; Bergey C.M.; Rogers J.; Phillips-Conroy J.E.; Jolly C.J.; Melin A.D.; Storz J.F.; Lu A.; Beehner J.C.; Bergman T.J.; Snyder-Mackler N.
发表日期	2022
ISSN	2397-334X
起始页码	630
结束页码	643
卷号	6 期号:5
英文摘要	Primates have adapted to numerous environments and lifestyles but very few species are native to high elevations. Here we investigated high-altitude adaptations in the gelada (Theropithecus gelada), a monkey endemic to the Ethiopian Plateau. We examined genome-wide variation in conjunction with measurements of haematological and morphological traits. Our new gelada reference genome is highly intact and assembled at chromosome-length levels. Unexpectedly, we identified a chromosomal polymorphism in geladas that could potentially contribute to reproductive barriers between populations. Compared with baboons at low altitude, we found that high-altitude geladas exhibit significantly expanded chest circumferences, potentially allowing for greater lung surface area for increased oxygen diffusion. We identified gelada-specific amino acid substitutions in the alpha-chain subunit of adult haemoglobin but found that gelada haemoglobin does not exhibit markedly altered oxygenation properties compared with lowland primates. We also found that geladas at high altitude do not exhibit elevated blood haemoglobin concentrations, in contrast to the normal acclimatization response to hypoxia in lowland primates. The absence of altitude-related polycythaemia suggests that geladas are able to sustain adequate tissue-oxygen delivery despite environmental hypoxia. Finally, we identified numerous genes and genomic regions exhibiting accelerated rates of evolution, as well as gene families exhibiting expansions in the gelada lineage, potentially reflecting altitude-related selection. Our findings lend insight into putative mechanisms of high-altitude adaptation while suggesting promising avenues for functional hypoxia research. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	oxygen; altitude; animal; chromosome; genomics; hypoxia; physiology; Theropithecus; Altitude; Animals; Chromosomes; Genomics; Hypoxia; Oxygen; Theropithecus
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257069
作者单位	Center for Evolution and Medicine, Arizona State University, Tempe, AZ, United States; School of Life Sciences, Arizona State University, Tempe, AZ, United States; Department of Psychology, University of Washington, Seattle, WA, United States; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA, United States; Department of Anthropology and Archaeology, University of Calgary, Calgary, AB, Canada; School of Science, Engineering, and Environment, University of Salford, Salford, United Kingdom; Department of Anthropology, University of Michigan, Ann Arbor, MI, United States; College of Veterinary Medicine and Agriculture, Addis Ababa University, Debre Zeit, Ethiopia; Veterinary Unit, Conservation Science Department, Tanzania National Parks (TANAPA), Arusha, Tanzania; Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, G?ttingen, Germany; Institute for International Animal Health/One H...
推荐引用方式 GB/T 7714	Chiou K.L.,Janiak M.C.,Schneider-Crease I.A.,et al. Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas[J],2022,6(5).
APA	Chiou K.L..,Janiak M.C..,Schneider-Crease I.A..,Sen S..,Ayele F..,...&Snyder-Mackler N..(2022).Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas.Nature Ecology & Evolution,6(5).
MLA	Chiou K.L.,et al."Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas".Nature Ecology & Evolution 6.5(2022).