气候变化领域集成服务门户(CCPortal): Polarization of microbial communities between competitive and cooperative metabolism

CCPortal

DOI	10.1038/s41559-020-01353-4
	Polarization of microbial communities between competitive and cooperative metabolism
	Machado D.; Maistrenko O.M.; Andrejev S.; Kim Y.; Bork P.; Patil K.R.; Patil K.R.
发表日期	2021
ISSN	2397-334X
起始页码	195
结束页码	203
卷号	5 期号:2
英文摘要	Resource competition and metabolic cross-feeding are among the main drivers of microbial community assembly. Yet the degree to which these two conflicting forces are reflected in the composition of natural communities has not been systematically investigated. Here, we use genome-scale metabolic modelling to assess the potential for resource competition and metabolic cooperation in large co-occurring groups (up to 40 members) across thousands of habitats. Our analysis reveals two distinct community types, which are clustered at opposite ends of a spectrum in a trade-off between competition and cooperation. At one end are highly cooperative communities, characterized by smaller genomes and multiple auxotrophies. At the other end are highly competitive communities, which feature larger genomes and overlapping nutritional requirements, and harbour more genes related to antimicrobial activity. The latter are mainly present in soils, whereas the former are found in both free-living and host-associated habitats. Community-scale flux simulations show that, whereas competitive communities can better resist species invasion but not nutrient shift, cooperative communities are susceptible to species invasion but resilient to nutrient change. We also show, by analysing an additional data set, that colonization by probiotic species is positively associated with the presence of cooperative species in the recipient microbiome. Together, our results highlight the bifurcation between competitive and cooperative metabolism in the assembly of natural communities and its implications for community modulation. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	microflora; Microbiota; Nutrients
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257026
作者单位	European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Medical Research Council (MRC) Toxicology Unit, University of Cambridge, Cambridge, United Kingdom
推荐引用方式 GB/T 7714	Machado D.,Maistrenko O.M.,Andrejev S.,et al. Polarization of microbial communities between competitive and cooperative metabolism[J],2021,5(2).
APA	Machado D..,Maistrenko O.M..,Andrejev S..,Kim Y..,Bork P..,...&Patil K.R..(2021).Polarization of microbial communities between competitive and cooperative metabolism.Nature Ecology & Evolution,5(2).
MLA	Machado D.,et al."Polarization of microbial communities between competitive and cooperative metabolism".Nature Ecology & Evolution 5.2(2021).