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DOI	10.1038/s41559-020-01367-y
	Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations
	Miroshnychenko D.; Baratchart E.; Ferrall-Fairbanks M.C.; Velde R.V.; Laurie M.A.; Bui M.M.; Tan A.C.; Altrock P.M.; Basanta D.; Marusyk A.
发表日期	2021
ISSN	2397-334X
起始页码	379
结束页码	391
卷号	5 期号:3
英文摘要	The initiation and progression of cancers reflect the underlying process of somatic evolution, in which the diversification of heritable phenotypes provides a substrate for natural selection, resulting in the outgrowth of the most fit subpopulations. Although somatic evolution can tap into multiple sources of diversification, it is assumed to lack access to (para)sexual recombination—a key diversification mechanism throughout all strata of life. On the basis of observations of spontaneous fusions involving cancer cells, the reported genetic instability of polypoid cells and the precedence of fusion-mediated parasexual recombination in fungi, we asked whether cell fusions between genetically distinct cancer cells could produce parasexual recombination. Using differentially labelled tumour cells, we found evidence of low-frequency, spontaneous cell fusions between carcinoma cells in multiple cell line models of breast cancer both in vitro and in vivo. While some hybrids remained polyploid, many displayed partial ploidy reduction, generating diverse progeny with heterogeneous inheritance of parental alleles, indicative of partial recombination. Hybrid cells also displayed elevated levels of phenotypic plasticity, which may further amplify the impact of cell fusions on the diversification of phenotypic traits. Using mathematical modelling, we demonstrated that the observed rates of spontaneous somatic cell fusions may enable populations of tumour cells to amplify clonal heterogeneity, thus facilitating the exploration of larger areas of the adaptive landscape (relative to strictly asexual populations), which may substantially accelerate a tumour’s ability to adapt to new selective pressures. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	cell fusion; clonal evolution; diploidy; genetic recombination; human; neoplasm; Cell Fusion; Clonal Evolution; Diploidy; Humans; Neoplasms; Recombination, Genetic
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257008
作者单位	Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States; Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States; Department of Molecular Medicine, University of South Florida, Tampa, FL, United States; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
推荐引用方式 GB/T 7714	Miroshnychenko D.,Baratchart E.,Ferrall-Fairbanks M.C.,et al. Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations[J],2021,5(3).
APA	Miroshnychenko D..,Baratchart E..,Ferrall-Fairbanks M.C..,Velde R.V..,Laurie M.A..,...&Marusyk A..(2021).Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations.Nature Ecology & Evolution,5(3).
MLA	Miroshnychenko D.,et al."Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations".Nature Ecology & Evolution 5.3(2021).