气候变化领域集成服务门户(CCPortal): The emergence of the brain non-CpG methylation system in vertebrates

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DOI	10.1038/s41559-020-01371-2
	The emergence of the brain non-CpG methylation system in vertebrates
	de Mendoza A.; Poppe D.; Buckberry S.; Pflueger J.; Albertin C.B.; Daish T.; Bertrand S.; de la Calle-Mustienes E.; Gómez-Skarmeta J.L.; Nery J.R.; Ecker J.R.; Baer B.; Ragsdale C.W.; Grützner F.; Escriva H.; Venkatesh B.; Bogdanovic O.; Lister R.
发表日期	2021
ISSN	2397-334X
起始页码	369
结束页码	378
卷号	5 期号:3
英文摘要	Mammalian brains feature exceptionally high levels of non-CpG DNA methylation alongside the canonical form of CpG methylation. Non-CpG methylation plays a critical regulatory role in cognitive function, which is mediated by the binding of MeCP2, the transcriptional regulator that when mutated causes Rett syndrome. However, it is unclear whether the non-CpG neural methylation system is restricted to mammalian species with complex cognitive abilities or has deeper evolutionary origins. To test this, we investigated brain DNA methylation across 12 distantly related animal lineages, revealing that non-CpG methylation is restricted to vertebrates. We discovered that in vertebrates, non-CpG methylation is enriched within a highly conserved set of developmental genes transcriptionally repressed in adult brains, indicating that it demarcates a deeply conserved regulatory program. We also found that the writer of non-CpG methylation, DNMT3A, and the reader, MeCP2, originated at the onset of vertebrates as a result of the ancestral vertebrate whole-genome duplication. Together, we demonstrate how this novel layer of epigenetic information assembled at the root of vertebrates and gained new regulatory roles independent of the ancestral form of the canonical CpG methylation. This suggests that the emergence of non-CpG methylation may have fostered the evolution of sophisticated cognitive abilities found in the vertebrate lineage. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	methyl CpG binding protein 2; animal; brain; DNA methylation; genetics; genome; metabolism; vertebrate; Animals; Brain; DNA Methylation; Genome; Methyl-CpG-Binding Protein 2; Vertebrates
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257007
作者单位	Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, WA, Australia; Harry Perkins Institute of Medical Research, Perth, WA, Australia; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom; Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, United States; Department of Neurobiology, University of Chicago, Chicago, IL, United States; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia; Sorbonne Université, CNRS, Biologie Intégrative des Organismes Marins (BIOM), Observatoire Océanologique, Banyuls-sur-Mer, France; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain; Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States; Howard Hughes Medical Institute, The Salk Institute f...
推荐引用方式 GB/T 7714	de Mendoza A.,Poppe D.,Buckberry S.,et al. The emergence of the brain non-CpG methylation system in vertebrates[J],2021,5(3).
APA	de Mendoza A..,Poppe D..,Buckberry S..,Pflueger J..,Albertin C.B..,...&Lister R..(2021).The emergence of the brain non-CpG methylation system in vertebrates.Nature Ecology & Evolution,5(3).
MLA	de Mendoza A.,et al."The emergence of the brain non-CpG methylation system in vertebrates".Nature Ecology & Evolution 5.3(2021).