气候变化领域集成服务门户(CCPortal): Using ecological coexistence theory to understand antibiotic resistance and microbial competition

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DOI	10.1038/s41559-020-01385-w
	Using ecological coexistence theory to understand antibiotic resistance and microbial competition
	Letten A.D.; Hall A.R.; Levine J.M.
发表日期	2021
ISSN	2397-334X
起始页码	431
结束页码	441
卷号	5 期号:4
英文摘要	Tackling antibiotic resistance necessitates deep understanding of how resource competition within and between species modulates the fitness of resistant microbes. Recent advances in ecological coexistence theory offer a powerful framework to probe the mechanisms regulating intra- and interspecific competition, but the significance of this body of theory to the problem of antibiotic resistance has been largely overlooked. In this Perspective, we draw on emerging ecological theory to illustrate how changes in resource niche overlap can be equally important as changes in competitive ability for understanding costs of resistance and the persistence of resistant pathogens in microbial communities. We then show how different temporal patterns of resource and antibiotic supply, alongside trade-offs in competitive ability at high and low resource concentrations, can have diametrically opposing consequences for the coexistence and exclusion of resistant and susceptible strains. These insights highlight numerous opportunities for innovative experimental and theoretical research into the ecological dimensions of antibiotic resistance. ? 2021, Springer Nature Limited.
语种	英语
scopus关键词	antibiotic resistance; Drug Resistance, Microbial
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/256998
作者单位	School of Biological Sciences, University of Queensland, Brisbane, QLD, Australia; Department of Environmental Systems Science, Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States
推荐引用方式 GB/T 7714	Letten A.D.,Hall A.R.,Levine J.M.. Using ecological coexistence theory to understand antibiotic resistance and microbial competition[J],2021,5(4).
APA	Letten A.D.,Hall A.R.,&Levine J.M..(2021).Using ecological coexistence theory to understand antibiotic resistance and microbial competition.Nature Ecology & Evolution,5(4).
MLA	Letten A.D.,et al."Using ecological coexistence theory to understand antibiotic resistance and microbial competition".Nature Ecology & Evolution 5.4(2021).