气候变化领域集成服务门户(CCPortal): ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

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DOI	10.1038/s41559-021-01407-1
	ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species
	Yan H.; Jiao H.; Liu Q.; Zhang Z.; Xiong Q.; Wang B.-J.; Wang X.; Guo M.; Wang L.-F.; Lan K.; Chen Y.; Zhao H.
发表日期	2021
ISSN	2397-334X
起始页码	600
结束页码	608
卷号	5 期号:5
英文摘要	Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus (SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, SARS-CoV-2. The interaction of viral spike proteins with their host receptor angiotensin-converting enzyme 2 (ACE2) is a critical determinant of potential hosts and cross-species transmission. Here we use virus–host receptor binding and infection assays to examine 46 ACE2 orthologues from phylogenetically diverse bat species, including those in close and distant contact with humans. We found that 24, 21 and 16 of them failed to support infection by SARS-CoV, SARS-CoV-2 or both viruses, respectively. Furthermore, we confirmed that infection assays in human cells were consistent with those in two bat cell lines. Additionally, we used genetic and functional analyses to identify critical residues in bat ACE2 receptors associated with viral entry restrictions. Our results suggest that many bat species may not be the potential hosts of one or both viruses and that no correlation was identified between proximity to humans and probability of being natural hosts of SARS-CoV or SARS-CoV-2. This study demonstrates dramatic variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species and adds knowledge towards a better understanding of coronavirus–bat interaction. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.
语种	英语
scopus关键词	coronavirus spike glycoprotein; dipeptidyl carboxypeptidase; virus receptor; animal; bat; genetics; human; Angiotensin-Converting Enzyme 2; Animals; Chiroptera; COVID-19; Humans; Peptidyl-Dipeptidase A; Receptors, Virus; SARS-CoV-2; Spike Glycoprotein, Coronavirus
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/256980
作者单位	State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Department of Ecology, Tibetan Centre for Ecology and Conservation at WHU-TU, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Duke-NUS Medical School, Singapore, Singapore; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
推荐引用方式 GB/T 7714	Yan H.,Jiao H.,Liu Q.,et al. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species[J],2021,5(5).
APA	Yan H..,Jiao H..,Liu Q..,Zhang Z..,Xiong Q..,...&Zhao H..(2021).ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species.Nature Ecology & Evolution,5(5).
MLA	Yan H.,et al."ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species".Nature Ecology & Evolution 5.5(2021).