气候变化领域集成服务门户(CCPortal): Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans

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DOI	10.1038/s41559-021-01435-x
	Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans
	Lee D.; Zdraljevic S.; Stevens L.; Wang Y.; Tanny R.E.; Crombie T.A.; Cook D.E.; Webster A.K.; Chirakar R.; Baugh L.R.; Sterken M.G.; Braendle C.; Félix M.-A.; Rockman M.V.; Andersen E.C.
发表日期	2021
ISSN	2397-334X
起始页码	794
结束页码	807
卷号	5 期号:6
英文摘要	Across diverse taxa, selfing species have evolved independently from outcrossing species thousands of times. The transition from outcrossing to selfing decreases the effective population size, effective recombination rate and heterozygosity within a species. These changes lead to a reduction in genetic diversity, and therefore adaptive potential, by intensifying the effects of random genetic drift and linked selection. Within the nematode genus Caenorhabditis, selfing has evolved at least three times, and all three species, including the model organism Caenorhabditis elegans, show substantially reduced genetic diversity relative to outcrossing species. Selfing and outcrossing Caenorhabditis species are often found in the same niches, but we still do not know how selfing species with limited genetic diversity can adapt to these environments. Here, we examine the whole-genome sequences from 609 wild C. elegans strains isolated worldwide and show that genetic variation is concentrated in punctuated hyper-divergent regions that cover 20% of the C. elegans reference genome. These regions are enriched in environmental response genes that mediate sensory perception, pathogen response and xenobiotic stress response. Population genomic evidence suggests that genetic diversity in these regions has been maintained by long-term balancing selection. Using long-read genome assemblies for 15 wild strains, we show that hyper-divergent haplotypes contain unique sets of genes and show levels of divergence comparable to levels found between Caenorhabditis species that diverged millions of years ago. These results provide an example of how species can avoid the evolutionary dead end associated with selfing. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	animal; Caenorhabditis elegans; evolution; genetic variation; genetics; genome; haplotype; Animals; Biological Evolution; Caenorhabditis elegans; Genetic Variation; Genome; Haplotypes
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/256950
作者单位	Department of Molecular Biosciences, Northwestern University, Evanston, IL, United States; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, United States; Department of Biology, Duke University, Durham, NC, United States; University Program in Genetics and Genomics, Duke University, Durham, NC, United States; Center for Genomic and Computational Biology, Duke University, Durham, NC, United States; Laboratory of Nematology, Wageningen University and Research, Wageningen, Netherlands; Université C?te d’Azur, CNRS, Inserm, IBV, France, Nice, France; Institut de Biologie de l’Ecole Normale Supérieure, Centre National de la Recherche Scientifique, INSERM, école Normale Supérieure, Paris Sciences et Lettres, Paris, France; Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, United States; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Department of Human Genetics, University of California, Los An...
推荐引用方式 GB/T 7714	Lee D.,Zdraljevic S.,Stevens L.,et al. Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans[J],2021,5(6).
APA	Lee D..,Zdraljevic S..,Stevens L..,Wang Y..,Tanny R.E..,...&Andersen E.C..(2021).Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans.Nature Ecology & Evolution,5(6).
MLA	Lee D.,et al."Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans".Nature Ecology & Evolution 5.6(2021).