气候变化领域集成服务门户(CCPortal): Dog colour patterns explained by modular promoters of ancient canid origin

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DOI	10.1038/s41559-021-01524-x
	Dog colour patterns explained by modular promoters of ancient canid origin
	Bannasch D.L.; Kaelin C.B.; Letko A.; Loechel R.; Hug P.; Jagannathan V.; Henkel J.; Roosje P.; Hyt?nen M.K.; Lohi H.; Arumilli M.; Kere J.; Daub C.; Hyt?nen M.; Araujo C.L.; Quintero I.B.; Ky?stil? K.; Kaukonen M.; Arumilli M.; Salonen M.; Sarviaho R.; Niskanen J.; Hundi S.; Puurunen J.; Sulkama S.; Karjalainen S.; Sukura A.; Syrj? P.; Airas N.; Pekkarinen H.; Kareinen I.; Knuuttila A.; Nordgren H.; Hagner K.; P??kk?nen T.; Iivanainen A.; Krjutskov K.; Ezer S.; Saarinen A.; Katayama S.; Yoshihara M.; H?rtenhuber M.; Aljelaify R.F.; Ross F.; Raman A.; Stevens I.; Gusev O.; Schoenebeck J.J.; Minor K.M.; Mickelson J.R.; Dr?gemüller C.; Barsh G.S.; Leeb T.; DoGA consortium
发表日期	2021
ISSN	2397-334X
起始页码	1415
结束页码	1423
卷号	5 期号:10
英文摘要	Distinctive colour patterns in dogs are an integral component of canine diversity. Colour pattern differences are thought to have arisen from mutation and artificial selection during and after domestication from wolves but important gaps remain in understanding how these patterns evolved and are genetically controlled. In other mammals, variation at the ASIP gene controls both the temporal and spatial distribution of yellow and black pigments. Here, we identify independent regulatory modules for ventral and hair cycle ASIP expression, and we characterize their action and evolutionary origin. Structural variants define multiple alleles for each regulatory module and are combined in different ways to explain five distinctive dog colour patterns. Phylogenetic analysis reveals that the haplotype combination for one of these patterns is shared with Arctic white wolves and that its hair cycle-specific module probably originated from an extinct canid that diverged from grey wolves more than 2 million years ago. Natural selection for a lighter coat during the Pleistocene provided the genetic framework for widespread colour variation in dogs and wolves. ? 2021, The Author(s).
语种	英语
scopus关键词	animal; color; dog; domestication; genetic selection; genetics; phylogeny; wolf; Animals; Color; Dogs; Domestication; Phylogeny; Selection, Genetic; Wolves
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/256848
作者单位	Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, United States; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland; HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States; Department of Genetics, Stanford University, Stanford, CA, United States; Dermfocus, University of Bern, Bern, Switzerland; VetGen, Ann Arbor, MI, United States; Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Folkh?lsan Research Center, Helsinki, Finland; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN, United States; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Department of Medical and C...
推荐引用方式 GB/T 7714	Bannasch D.L.,Kaelin C.B.,Letko A.,et al. Dog colour patterns explained by modular promoters of ancient canid origin[J],2021,5(10).
APA	Bannasch D.L..,Kaelin C.B..,Letko A..,Loechel R..,Hug P..,...&DoGA consortium.(2021).Dog colour patterns explained by modular promoters of ancient canid origin.Nature Ecology & Evolution,5(10).
MLA	Bannasch D.L.,et al."Dog colour patterns explained by modular promoters of ancient canid origin".Nature Ecology & Evolution 5.10(2021).