气候变化领域集成服务门户(CCPortal): Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat

CCPortal

DOI	10.1111/mec.16194
	Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat
	Chen, Yi; Hou, Guanmei; Jing, Meidong; Teng, Huajing; Liu, Quansheng; Yang, Xingen; Wang, Yong; Qu, Jiapeng; Shi, Chengmin; Lu, Liang; Zhang, Jianxu; Zhang, Yaohua
通讯作者	Zhang, JX ; Zhang, YH (通讯作者)，Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China. ; Lu, L (通讯作者)，Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China.
发表日期	2021
ISSN	0962-1083
EISSN	1365-294X
起始页码	6596
结束页码	6610
卷号	30 期号:24
英文摘要	The Asian house rat (AHR), Rattus tanezumi, has recently invaded the northern half of China. The AHR is a highly adaptive rat species that has also successfully conquered the Qinghai-Tibet Plateau (QTP) and replaced the brown rat (BR), R. norvegicus, at the edge of the QTP. Here, we assembled a draft genome of the AHR and explored the mechanisms of its northward invasion and the genetic basis underlying plateau adaptation in this species. Population genomic analyses revealed that the northwardly invasive AHRs consisted of two independent and genetically distinct populations which might result from multiple independent primary invasion events. One invasive population exhibited reduced genetic diversity and distinct population structure compared with its source population, while the other displayed preserved genetic polymorphisms and little genetic differentiation from its source population. Genes involved in G-protein coupled receptors and carbohydrate metabolism may contribute to the local adaptation of northern AHRs. In particular, RTN4 was identified as a key gene for AHRs in the QTP that favours adaptation to high-altitude hypoxia. Coincidently, the physiological performance and transcriptome profiles of hypoxia-exposed rats both showed better hypoxia adaptation in AHRs than in BRs that failed to colonize the heart of the QTP, which may have facilitated the replacement of the BR population by the invading AHRs at the edge of the QTP. This study provides profound insights into the multiple origins of the northwardly invasive AHR and the great tolerance to hypoxia in this species.
关键词	THYROTROPIN-RELEASING-HORMONE GENETIC-VARIATION NOGO EVOLUTIONARY ALIGNMENT PROTEIN INTROGRESSION HYBRIDIZATION CONSEQUENCES PLASTICITY
英文关键词	colonization pattern; hypoxia adaptation; invasion mechanism; northward invasion; Rattus tanezumi; reference genome
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:000712838300001
来源期刊	MOLECULAR ECOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255196
作者单位	[Chen, Yi; Hou, Guanmei; Teng, Huajing; Zhang, Jianxu; Zhang, Yaohua] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China; [Chen, Yi; Hou, Guanmei; Zhang, Jianxu; Zhang, Yaohua] Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China; [Jing, Meidong] Nantong Univ, Sch Life Sci, Nantong, Peoples R China; [Teng, Huajing] Peking Univ, Dept Radiat Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Canc Hosp & Inst, Beijing, Peoples R China; [Liu, Quansheng] Guangdong Acad Sci, Inst Zool, Guangdong Key Lab Anim Conservat & Resource Utili, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangzhou, Peoples R China; [Yang, Xingen] Shanxi Acad Agr Sci, Inst Plant Protect, Shanxi Key Lab Integrated Pest Management Agr, Taiyuan, Peoples R China; [Wang, Yong] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Dongting Lake Stn Wetland Ecosyst Res, Changsha, Peoples R China; [Qu, Jiapeng] Chinese Acad Sc...
推荐引用方式 GB/T 7714	Chen, Yi,Hou, Guanmei,Jing, Meidong,et al. Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat[J]. 中国科学院西北生态环境资源研究院,2021,30(24).
APA	Chen, Yi.,Hou, Guanmei.,Jing, Meidong.,Teng, Huajing.,Liu, Quansheng.,...&Zhang, Yaohua.(2021).Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat.MOLECULAR ECOLOGY,30(24).
MLA	Chen, Yi,et al."Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat".MOLECULAR ECOLOGY 30.24(2021).