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DOI	10.1016/j.micromeso.2020.110713
	Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery
	Zhao, Kai; Gong, Peiwei; Huang, Jie; Huang, Yan; Wang, Dandan; Peng, Jingyi; Shen, Duyi; Zheng, Xiaofeng; You, Jinmao; Liu, Zhe
通讯作者	Gong, PW ; Liu, Z (通讯作者)，Qufu Normal Univ, Dept Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China. ; Gong, PW ; Liu, Z (通讯作者)，Qufu Normal Univ, Dept Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China. ; Huang, J (通讯作者)，Qingdao Univ Sci & Technol, Qingdao 266061, Peoples R China.
发表日期	2021
ISSN	1387-1811
EISSN	1873-3093
卷号	311
英文摘要	Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by turn-off fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4@COF in the application of cancer chemo-photothermal therapy.
关键词	COVALENT ORGANIC FRAMEWORKS FLUORINATED GRAPHENE TUMOR ABSORPTION PARTICLES
英文关键词	COFs; Fluorescence; Surface modification; Core-shell structure; Drug delivery
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Applied ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000601002900004
来源期刊	MICROPOROUS AND MESOPOROUS MATERIALS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255128
作者单位	[Zhao, Kai; Gong, Peiwei; Huang, Yan; Wang, Dandan; Peng, Jingyi; Shen, Duyi; Zheng, Xiaofeng; You, Jinmao; Liu, Zhe] Qufu Normal Univ, Dept Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China; [Zhao, Kai; Gong, Peiwei; Huang, Yan; Wang, Dandan; Peng, Jingyi; Shen, Duyi; Zheng, Xiaofeng; You, Jinmao; Liu, Zhe] Qufu Normal Univ, Dept Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China; [Huang, Jie] Qingdao Univ Sci & Technol, Qingdao 266061, Peoples R China; [You, Jinmao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Kai,Gong, Peiwei,Huang, Jie,et al. Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery[J]. 中国科学院西北生态环境资源研究院,2021,311.
APA	Zhao, Kai.,Gong, Peiwei.,Huang, Jie.,Huang, Yan.,Wang, Dandan.,...&Liu, Zhe.(2021).Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery.MICROPOROUS AND MESOPOROUS MATERIALS,311.
MLA	Zhao, Kai,et al."Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery".MICROPOROUS AND MESOPOROUS MATERIALS 311(2021).