气候变化领域集成服务门户(CCPortal): Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii

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DOI	10.1016/j.cclet.2020.10.027
	Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii
	Zhen, Bo; Suo, Xinyue; Dang, Jun; Yue, Huilan; Tao, Yanduo; Wang, Jia-Jia; Li, Li; Lin, Ming-Bao; Hou, Qi; Wang, Wei-Ping; Wang, Xiao-Liang; Jiang, Jian-Dong; Ji, Teng-Fei
通讯作者	Jiang, JD ; Ji, TF (通讯作者)，Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China. ; Jiang, JD ; Ji, TF (通讯作者)，Peking Union Med Coll, Beijing 100050, Peoples R China.
发表日期	2021
ISSN	1001-8417
EISSN	1878-5964
起始页码	2338
结束页码	2341
卷号	32 期号:7
英文摘要	Hyperterpenoid A (1) and B (2), two pairs of enantiomers, with an unprecedented 6/6/4/6/6 polycyclic skeleton, along with one known compoud hypermonone A (3) were isolated from Hypericum beanii. The racemate (+/-)-1 and (+/-)-2 were successfully separated into the two optically pure enantiomers (ee >= 99%) using a preparative HPLC system. Their absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction method. The related plausible biogenetic pathways were presented. Compound 1-3 showed significant neuroprotective activity and potential anti-inflammatory activity. The result that (+)-2 and (-)-2 presented different anti-inflammatory properties, may lead us to new discovery of structure activity relationship between racemates, enantiomers, and diastereomers, as well as further research regarding the binding of drugs to target proteins. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
关键词	ACYLPHLOROGLUCINOLS METABOLITES DERIVATIVES
英文关键词	Hypericum beanii; Meroterpenoids; (+/-)-Hyperterpenoid A and B; Anti-inflammatory activity; Neuroprotective activity
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000669786000020
来源期刊	CHINESE CHEMICAL LETTERS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255020
作者单位	[Zhen, Bo; Suo, Xinyue; Wang, Jia-Jia; Li, Li; Lin, Ming-Bao; Hou, Qi; Wang, Wei-Ping; Wang, Xiao-Liang; Jiang, Jian-Dong; Ji, Teng-Fei] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China; [Zhen, Bo; Suo, Xinyue; Wang, Jia-Jia; Li, Li; Lin, Ming-Bao; Hou, Qi; Wang, Wei-Ping; Wang, Xiao-Liang; Jiang, Jian-Dong; Ji, Teng-Fei] Peking Union Med Coll, Beijing 100050, Peoples R China; [Dang, Jun; Yue, Huilan; Tao, Yanduo] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Zhen, Bo,Suo, Xinyue,Dang, Jun,et al. Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii[J]. 中国科学院西北生态环境资源研究院,2021,32(7).
APA	Zhen, Bo.,Suo, Xinyue.,Dang, Jun.,Yue, Huilan.,Tao, Yanduo.,...&Ji, Teng-Fei.(2021).Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii.CHINESE CHEMICAL LETTERS,32(7).
MLA	Zhen, Bo,et al."Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii".CHINESE CHEMICAL LETTERS 32.7(2021).