气候变化领域集成服务门户(CCPortal): Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets

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DOI	10.1016/j.foodchem.2020.128672
	Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets
	Zhang, Xinxin; Wang, Xingbin; Xue, Zhaowei; Zhan, Guanqun; Ito, Yoichiro; Guo, Zengjun
通讯作者	Guo, ZJ (通讯作者)，Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta Rd, Xian 710061, Peoples R China. ; Ito, Y (通讯作者)，NHLBI, Lab Bioseparat Technol, Biochem & Biophys Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA.
发表日期	2021
ISSN	0308-8146
EISSN	1873-7072
卷号	345
英文摘要	I/R (cerebral ischemia reperfusion injury) is the secondary complication of ischemic stroke patients that are immediately treated with drug thrombolysis or vascular recanalization in clinic. Diosgenin (DIO) purified from medicine food homologous (MFH) Dioscorea yam source is served as a fatal starting material to synthesize multifarious steroidal anti-inflammatory drugs in medicinal field, and has previously been demonstrated the potential prevention of I/R. However, the detailed mechanisms of neumprotective effects against I/R remain elusively understood. Here, a global proteomic dynamics of rat right hemisphere brains was executed to investigate the protein expression patterns with a quantitative LC-MSn. In total, 5043 proteins were identified and 418 ones were determined to be significantly dysregulated DEPs (differentially expressed proteins) in comparison of Sham verse I/R and I/R verse DIO after onset stage of I/R, among which 5 DEPs namely BICD2, HNRNPK, CEP41, PPM1K, and ARL2BP, whose biological functions were mainly clustered into the mediation of nervous system, were selected for further validation in vitro and in vivo, and the change tendency expectedly supported the proteomic findings. Additionally, the AUC value of the combined ROC of these 5 DEPs was 0.988 with P < 0.0001, higher than every single one. Collectively, these scientific findings attributed to a typical investigation of dietary Dioscorea-enriched diosgenin in MFH research, suggesting that diosgenin or its derivatives were potential to be developed into food supplements or healthy food products to reveal healthy benefits in natural prevention and reduction risk of I/R. This work also promoted reasonable consumption of Dioscorea yams and contributed to the function of diosgenin-derived products and their applications in food industry.
英文关键词	Cerebral ischemia reperfusion; Diosgenin-derived products; Edible Dioscorea yams; Medicine food homologous; Food therapy
语种	英语
WOS研究方向	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS类目	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000619235900008
来源期刊	FOOD CHEMISTRY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255009
作者单位	[Zhang, Xinxin; Wang, Xingbin; Xue, Zhaowei; Zhan, Guanqun; Guo, Zengjun] Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta Rd, Xian 710061, Peoples R China; [Zhang, Xinxin] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China; [Ito, Yoichiro] NHLBI, Lab Bioseparat Technol, Biochem & Biophys Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Zhang, Xinxin,Wang, Xingbin,Xue, Zhaowei,et al. Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets[J]. 中国科学院西北生态环境资源研究院,2021,345.
APA	Zhang, Xinxin,Wang, Xingbin,Xue, Zhaowei,Zhan, Guanqun,Ito, Yoichiro,&Guo, Zengjun.(2021).Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets.FOOD CHEMISTRY,345.
MLA	Zhang, Xinxin,et al."Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets".FOOD CHEMISTRY 345(2021).