气候变化领域集成服务门户(CCPortal): Visualizing the hypoxic heterogeneity for distinguishing the cancer tissues with a two-photon nitroreductase-H2S logic probe via intramolecular isomerization

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DOI	10.1016/j.snb.2021.130647
	Visualizing the hypoxic heterogeneity for distinguishing the cancer tissues with a two-photon nitroreductase-H2S logic probe via intramolecular isomerization
	Xue, Junlian; Liu, Yuxia; Li, Lu; Xu, Jie; Chen, Tao; Li, Yulin; Chen, Guang
通讯作者	Liu, YX ; Chen, G (通讯作者)，Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Key Lab Chem Addit China Natl Light Ind, Xian 710021, Peoples R China.
发表日期	2021
EISSN	0925-4005
卷号	347
英文摘要	The uncontrollable growth of tumor leads to the heterogeneity of hypoxia, which is more complicated than researchers have detected using a single factor. Using two factors to reveal the heterogeneous hypoxic environment would be more accurate for distinguishing the cancerous tissues. Herein, we develop a two-photon fluorescence probe (E)-1-(2-(2,4-dinitrophenoxy)naphthalen-1-yl)-2-(4-nitrophenyl)diazene (DNHF) featuring the logic responses toward two factors nitroreductase (NTR) and H2S via intramolecular isomerization, for the imaging of the hypoxic heterogeneity. DNHF is transformed respectively by H2S or NTR to a hydrazone structure (DND) or a reduced product DAHF. Interestingly, DND and DAHF is almost quenched due to the interinhibitive effect or the hydrazone isomerization. While the product AHF triggered by the coexistent high level of NTR and H2S shows strong fluorescence via an intermolecular isomerization to the azo-structure AHF-2. These properties enable DNHF to reveal the severe hypoxia (high NTR and H2S) by releasing the strong fluorescence and the mild hypoxia (low NTR or H2S) by releasing the weak fluorescence, thereby visualizing the hypoxic heterogeneity by two factors. With the DNHF, the heterogeneity difference between normal and tumor tissues is enhanced. We envision this probe may serve as an effective tool for the accurate analysis of cancer tissues.
关键词	FLUORESCENT-PROBES REDUCTIVE STRESS IN-VIVO CELLS MODEL
英文关键词	Nitroreductase-H2S logic probe; Hypoxic heterogeneity; Intramolecular isomerization; Tumor tissue
语种	英语
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS类目	Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS记录号	WOS:000697559500005
来源期刊	SENSORS AND ACTUATORS B-CHEMICAL
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255003
作者单位	[Xue, Junlian; Liu, Yuxia; Li, Lu; Xu, Jie; Chen, Guang] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Key Lab Chem Addit China Natl Light Ind, Xian 710021, Peoples R China; [Chen, Tao; Li, Yulin] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810001, Qinghai, Peoples R China; [Liu, Yuxia; Chen, Guang] Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada; [Liu, Yuxia; Chen, Guang] Univ Waterloo, Waterloo Inst Nanotechnol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
推荐引用方式 GB/T 7714	Xue, Junlian,Liu, Yuxia,Li, Lu,et al. Visualizing the hypoxic heterogeneity for distinguishing the cancer tissues with a two-photon nitroreductase-H2S logic probe via intramolecular isomerization[J]. 中国科学院西北生态环境资源研究院,2021,347.
APA	Xue, Junlian.,Liu, Yuxia.,Li, Lu.,Xu, Jie.,Chen, Tao.,...&Chen, Guang.(2021).Visualizing the hypoxic heterogeneity for distinguishing the cancer tissues with a two-photon nitroreductase-H2S logic probe via intramolecular isomerization.SENSORS AND ACTUATORS B-CHEMICAL,347.
MLA	Xue, Junlian,et al."Visualizing the hypoxic heterogeneity for distinguishing the cancer tissues with a two-photon nitroreductase-H2S logic probe via intramolecular isomerization".SENSORS AND ACTUATORS B-CHEMICAL 347(2021).