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DOI	10.1016/j.ccr.2020.213553
	Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease
	Ma, Siyue; Chen, Guang; Xu, Jie; Liu, Yuxia; Li, Guoliang; Chen, Tao; Li, Yulin; James, Tony D.
通讯作者	Chen, G ; Liu, YX ; James, TD (通讯作者)，Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China.
发表日期	2021
ISSN	0010-8545
EISSN	1873-3840
卷号	427
英文摘要	One of the most prevalent forms of dementia is Alzheimer's disease (AD) which causes severe memory impairment within humans. As such, research into the early diagnosis of AD is essential to help treatment, which has led to significant advances in fluorescence imaging. Unfortunately, modern medicine and biology place increasingly strict requirements for fluorescent probes. Therefore, over recent years, researchers have taken strides to develop novel fluorescent molecular probes, with properties suitable for modern clinical applications, including low phototoxicity, weak background interference, deep tissue penetration, enhanced specificity, strong binding affinity, and suitable permeability through the blood-brain barrier (BBB). From these recent research results, many novel concepts for molecular design and fluorescence techniques have emerged. Herein, we present strategies towards the development of probes capable of meeting the advanced clinical requirements. As part of this review, we will summarize the characteristic enzymes and proteins involved in AD progression, including Amyloid-beta, beta-secretase, tau protein, monoamine oxidases, and methionine sulfoxide reductase. Then, we will evaluate some of the early probes and summarize the recent advancements made in the design of probes suitable for clinical applications, from which several strategies have emerged, such as increasing permeability to the blood-brain barrier, enhancing specificity by boosting binding affinity, and improving optical properties for in vivo imaging, etc. Then to conclude current strategies for early stage diagnosis of AD will be presented, and the opportunities as well as the remaining challenges will be outlined. (C) 2020 Elsevier B.V. All rights reserved.
关键词	IN-VIVO DETECTION BETA-AMYLOID PLAQUES METHIONINE SULFOXIDE REDUCTASES MONOAMINE-OXIDASE-B IMAGING AGENTS LIVING CELLS BENZOTHIAZOLE DERIVATIVES NEUROFIBRILLARY TANGLES BENZOFURAN DERIVATIVES SELECTIVE DETECTION
英文关键词	Alzheimer's disease; Fluorescence imaging; Molecular Probes; Enzyme; Protein
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear
WOS记录号	WOS:000588407500027
来源期刊	COORDINATION CHEMISTRY REVIEWS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254932
作者单位	[Ma, Siyue; Chen, Guang; Li, Guoliang; James, Tony D.] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China; [Chen, Guang; Xu, Jie] Hainan Med Univ, Coll Emergency & Trauma, Key Lab Hainan Trauma & Disaster Rescue, Minist Educ, Haikou 571199, Hainan, Peoples R China; [James, Tony D.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England; [Liu, Yuxia] Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada; [Liu, Yuxia] Univ Waterloo, Waterloo Inst Nanotechnol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada; [Chen, Tao; Li, Yulin] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810001, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Ma, Siyue,Chen, Guang,Xu, Jie,et al. Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease[J]. 中国科学院西北生态环境资源研究院,2021,427.
APA	Ma, Siyue.,Chen, Guang.,Xu, Jie.,Liu, Yuxia.,Li, Guoliang.,...&James, Tony D..(2021).Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease.COORDINATION CHEMISTRY REVIEWS,427.
MLA	Ma, Siyue,et al."Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease".COORDINATION CHEMISTRY REVIEWS 427(2021).