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| DOI | 10.3389/fchem.2021.595991 |
| Current Advancements in Sactipeptide Natural Products | |
| Chen, Yunliang; Wang, Jinxiu; Li, Guoquan; Yang, Yunpeng; Ding, Wei | |
| 通讯作者 | Ding, W (通讯作者)，Shanghai Jiao Tong Univ, Joint Int Res Lab Metab & Dev Sci, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Shanghai, Peoples R China. |
| 发表日期 | 2021 |
| ISSN | 2296-2646 |
| 卷号 | 9 |
| 英文摘要 | Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products that benefited from genome sequencing technology in the past two decades. RiPPs are widely distributed in nature and show diverse chemical structures and rich biological activities. Despite the various structural characteristic of RiPPs, they follow a common biosynthetic logic: a precursor peptide containing an N-terminal leader peptide and a C-terminal core peptide; in some cases,a follower peptide is after the core peptide. The precursor peptide undergoes a series of modification, transport, and cleavage steps to form a mature natural product with specific activities. Sactipeptides (Sulfur-to-alpha carbon thioether cross-linked peptides) belong to RiPPs that show various biological activities such as antibacterial, spermicidal and hemolytic properties. Their common hallmark is an intramolecular thioether bond that crosslinks the sulfur atom of a cysteine residue to the alpha-carbon of an acceptor amino acid, which is catalyzed by a rSAM enzyme. This review summarizes recent achievements concerning the discovery, distribution, structural elucidation, biosynthesis and application prospects of sactipeptides. |
| 关键词 | THIOETHER BOND FORMATIONQUINOHEMOPROTEIN AMINE DEHYDROGENASERADICAL SAM ENZYMESBACTERIOCIN GENE CLUSTERSH-ATOM ABSTRACTIONTHURINCIN HANTIMICROBIAL ACTIVITYSUBTILOSIN-ATHURICIN CDMECHANISTIC INVESTIGATIONS |
| 英文关键词 | sactipeptide; antibaceterial; thioether; RiPPs; ribosomally produced and post-translationally modified peptides; SAM radical enzyme |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000657298200001 |
| 来源期刊 | FRONTIERS IN CHEMISTRY
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| 来源机构 | 中国科学院西北生态环境资源研究院 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/254892 |
| 作者单位 | [Chen, Yunliang; Ding, Wei] Shanghai Jiao Tong Univ, Joint Int Res Lab Metab & Dev Sci, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Shanghai, Peoples R China; [Chen, Yunliang; Li, Guoquan] Jiangsu Univ, Sch Agr Equipment Engn, Zhenjiang, Jiangsu, Peoples R China; [Wang, Jinxiu] Chinese Acad Sci, Northwest Inst Ecoenvironm & Resources, Lanzhou, Peoples R China; [Yang, Yunpeng] Chinese Acad Sci, Ctr Excellence Mol Plant Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yunliang,Wang, Jinxiu,Li, Guoquan,et al. Current Advancements in Sactipeptide Natural Products[J]. 中国科学院西北生态环境资源研究院,2021,9. |
| APA | Chen, Yunliang,Wang, Jinxiu,Li, Guoquan,Yang, Yunpeng,&Ding, Wei.(2021).Current Advancements in Sactipeptide Natural Products.FRONTIERS IN CHEMISTRY,9. |
| MLA | Chen, Yunliang,et al."Current Advancements in Sactipeptide Natural Products".FRONTIERS IN CHEMISTRY 9(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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