气候变化领域集成服务门户(CCPortal): Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi)

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DOI	10.1111/mec.16174
	Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi)
	Zhang, Tao; Chen, Jie; Zhang, Jia; Guo, Yuan-Ting; Zhou, Xin; Li, Meng-Wen; Zheng, Zhi-Zhong; Zhang, Tong-Zuo; Murphy, Robert W.; Nevo, Eviatar; Shi, Peng
通讯作者	Shi, P (通讯作者)，Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China.
发表日期	2021
ISSN	0962-1083
EISSN	1365-294X
起始页码	5765
结束页码	5779
卷号	30 期号:22
英文摘要	The evolutionary outcomes of high elevation adaptation have been extensively described. However, whether widely distributed high elevation endemic animals adopt uniform mechanisms during adaptation to different elevational environments remains unknown, especially with respect to extreme high elevation environments. To explore this, we analysed the phenotypic and genomic data of seven populations of plateau zokor (Myospalax baileyi) along elevations ranging from 2,700 to 4,300 m. Based on whole-genome sequencing data and demographic reconstruction of the evolutionary history, we show that two populations of plateau zokor living at elevations exceeding 3,700 m diverged from other populations nearly 10,000 years ago. Further, phenotypic comparisons reveal stress-dependent adaptation, as two populations living at elevations exceeding 3,700 m have elevated ratios of heart mass to body mass relative to other populations, and the highest population (4,300 m) displays alterations in erythrocytes. Correspondingly, genomic analysis of selective sweeps indicates that positive selection might contribute to the observed phenotypic alterations in these two extremely high elevation populations, with the adaptive cardiovascular phenotypes of both populations possibly evolving under the functional constrains of their common ancestral population. Taken together, phenotypic and genomic evidence demonstrates that heterogeneous stressors impact adaptations to extreme elevations and reveals stress-dependent and genetically constrained adaptation to hypoxia, collectively providing new insights into the high elevation adaptation.
关键词	HIGH-ALTITUDE ADAPTATION NATURAL-SELECTION GENETIC ADAPTATION REVEALS ADAPTATION MURINE MODELS MOLE-RATS HEART MUTATIONS MICE ASSOCIATION
英文关键词	heterogeneous stresses; high elevation adaptation; phenotype and genotype; plateau zokor
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:000698697500001
来源期刊	MOLECULAR ECOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254802
作者单位	[Zhang, Tao; Chen, Jie; Zhang, Jia; Guo, Yuan-Ting; Zhou, Xin; Li, Meng-Wen; Zheng, Zhi-Zhong; Murphy, Robert W.; Shi, Peng] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China; [Zhang, Tao; Chen, Jie; Guo, Yuan-Ting; Zhou, Xin; Zheng, Zhi-Zhong] Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China; [Zhang, Tong-Zuo] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Peoples R China; [Murphy, Robert W.] Royal Ontario Museum, Ctr Biodivers & Conservat Biol, Toronto, ON, Canada; [Nevo, Eviatar] Univ Haifa, Inst Evolut, Haifa, Israel; [Shi, Peng] Univ Chinese Acad Sci, Sch Future Technol, Beijing, Peoples R China; [Shi, Peng] Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Tao,Chen, Jie,Zhang, Jia,et al. Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi)[J]. 中国科学院西北生态环境资源研究院,2021,30(22).
APA	Zhang, Tao.,Chen, Jie.,Zhang, Jia.,Guo, Yuan-Ting.,Zhou, Xin.,...&Shi, Peng.(2021).Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi).MOLECULAR ECOLOGY,30(22).
MLA	Zhang, Tao,et al."Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi)".MOLECULAR ECOLOGY 30.22(2021).