气候变化领域集成服务门户(CCPortal): Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells

CCPortal

DOI	10.1007/s00284-021-02534-5
	Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells
	Liu, Yanxi; Li, Zhiqian; Wang, Shuo; Zhang, Changjian; Han, Li; Sun, Qun; Han, Xuelin
通讯作者	Sun, Q (通讯作者)，Sichuan Univ, Coll Life Sci, Minist Educ, Key Lab Bioresources & Ecoenvironm, Chengdu, Sichuan, Peoples R China. ; Han, XL (通讯作者)，Inst Dis Control & Prevent PLA, Dept Hosp Infect Control & Res, Beijing, Peoples R China.
发表日期	2021
ISSN	0343-8651
EISSN	1432-0991
起始页码	3474
结束页码	3482
卷号	78 期号:9
英文摘要	Invasive pulmonary aspergillosis induced by the pathogenic fungus Aspergillus fumigatus is one of the common fatal complications in immunocompromised patients. Lung epithelial cells play an important role in host immune defense against A. fumigatus. However, the interaction between lung epithelial cells and A. fumigatus conidia is not fully understood. In this study, we used the swollen conidia of A. fumigatus to stimulate the type II lung epithelial A549 cells. Results showed that swollen conidia could significantly increase RNA transcription and protein expression of interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1), but not TNF-alpha in A549 cells in a time-dependent manner. Moreover, serum opsonization was able to improve the release of inflammatory factors induced by swollen conidia. Blocking of the dectin-1 or CR3 receptors, or both simultaneously, in the A549 cells could decrease the release of IL-8 and MCP-1. Additionally, blocking dectin-1 or CR3 could inhibit the transcription of nuclear factor NF-kappa B that was activated by swollen conidia. Here we reported for the first time that dectin-1 and CR3 receptors in A549 cells mediate the release of pro-inflammatory factors IL-8 and MCP-1 induced by A. fumigatus.
关键词	NF-KAPPA-B AIRWAY INFLAMMATION COMPLEMENT RECEPTOR TNF-ALPHA CONIDIA CHEMOATTRACTANT STIMULATION MACROPHAGES NEUTROPHILS CD11B/CD18
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000673262700001
来源期刊	CURRENT MICROBIOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254759
作者单位	[Liu, Yanxi; Sun, Qun] Sichuan Univ, Coll Life Sci, Minist Educ, Key Lab Bioresources & Ecoenvironm, Chengdu, Sichuan, Peoples R China; [Liu, Yanxi; Li, Zhiqian; Zhang, Changjian; Han, Li; Han, Xuelin] Inst Dis Control & Prevent PLA, Dept Hosp Infect Control & Res, Beijing, Peoples R China; [Liu, Yanxi; Li, Zhiqian] PLA, Dept Clin Lab, Hosp 907, Fuzhou, Fujian, Peoples R China; [Wang, Shuo] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China; [Wang, Shuo] Qinghai Prov Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanxi,Li, Zhiqian,Wang, Shuo,et al. Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells[J]. 中国科学院西北生态环境资源研究院,2021,78(9).
APA	Liu, Yanxi.,Li, Zhiqian.,Wang, Shuo.,Zhang, Changjian.,Han, Li.,...&Han, Xuelin.(2021).Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells.CURRENT MICROBIOLOGY,78(9).
MLA	Liu, Yanxi,et al."Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells".CURRENT MICROBIOLOGY 78.9(2021).