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DOI	10.1007/s11250-021-02605-6
	Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing
	Li, Lei-Lei; Ma, Shi-Ke; Peng, Wei; Fang, You-Gui; Duo, Hai-Rui; Fu, Hong-Yun; Jia, Gong-Xue
通讯作者	Jia, GX (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Qinghai Key Lab Anim Ecol Genom, Xining 810001, Peoples R China.
发表日期	2021
ISSN	0049-4747
EISSN	1573-7438
卷号	53 期号:1
英文摘要	Tibetan sheep is one of primitive Chinese sheep breeds, which achieved the divergence about 2500 years ago in Qinghai plateau region. According to different geographic conditions, especially altitudes, Tibetan sheep evolved into different breeds. In this study, we performed whole genome resequencing of 5 representative Tibetan sheep breeds. Comparative genomic analysis showed that they can be divided into different clades with a close genetic relationship. However, some genes with common selective regions were enriched for hypoxic adaptability in different breeds living at higher altitude, including GHR, BMP15, and CPLANE1. Furthermore, breed-specific selective regions about physical characteristics, especially wool growth, were found in genes such as BSND, USP24, NCAPG, and LCORL. This study could contribute to our understanding about trait formation and offer a reference for breeding of Tibetan sheep.
关键词	REVEALS ADAPTATION GENERATION PATTERNS
英文关键词	Tibetan sheep; SNP; Adaptability; Candidate genes
语种	英语
WOS研究方向	Agriculture ; Veterinary Sciences
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences
WOS记录号	WOS:000620591300002
来源期刊	TROPICAL ANIMAL HEALTH AND PRODUCTION
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254673
作者单位	[Li, Lei-Lei] Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China; [Ma, Shi-Ke; Peng, Wei] Qinghai Univ, Qinghai Acad Anim Sci & Vet Med, Xining 810016, Peoples R China; [Fang, You-Gui; Jia, Gong-Xue] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Qinghai Key Lab Anim Ecol Genom, Xining 810001, Peoples R China; [Duo, Hai-Rui] Qinghai Normal Univ, Sch Geog Sci, Xining 810016, Peoples R China; [Fu, Hong-Yun] Qinghai Headquarter Anim Husb Extens Stn, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Li, Lei-Lei,Ma, Shi-Ke,Peng, Wei,et al. Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing[J]. 中国科学院西北生态环境资源研究院,2021,53(1).
APA	Li, Lei-Lei.,Ma, Shi-Ke.,Peng, Wei.,Fang, You-Gui.,Duo, Hai-Rui.,...&Jia, Gong-Xue.(2021).Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing.TROPICAL ANIMAL HEALTH AND PRODUCTION,53(1).
MLA	Li, Lei-Lei,et al."Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing".TROPICAL ANIMAL HEALTH AND PRODUCTION 53.1(2021).