气候变化领域集成服务门户(CCPortal): Shift of Maternal Gut Microbiota of Tibetan Antelope (Pantholops hodgsonii) During the Periparturition Period

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DOI	10.1007/s00284-020-02339-y
	Shift of Maternal Gut Microbiota of Tibetan Antelope (Pantholops hodgsonii) During the Periparturition Period
	Shi, Yue; Miao, Zi-Yan; Su, Jian-Ping; Wasser, Samuel K.
通讯作者	Shi, Y (通讯作者)，Univ Washington, Dept Biol, Box 351800, Seattle, WA 98195 USA. ; Shi, Y (通讯作者)，Univ Alaska Fairbanks, Coll Fisheries & Ocean Sci, 17101 Point Lena Loop Rd, Juneau, AK 99801 USA.
发表日期	2021
ISSN	0343-8651
EISSN	1432-0991
起始页码	727
结束页码	738
卷号	78 期号:2
英文摘要	The maternal gut microbiota can influence and be affected by the substantial physiological changes taking place during the periparturition period. However, little information is known about the changes in the maternal gut microbiota and hormonal variations during this period in nonmodel organisms. Tibetan antelope (Pantholops hodgsonii) provide a unique system to address this issue because their summer migration cycle is synchronized with the periparturition period. Here, we used fecal microbiota as a proxy of gut microbiota. We characterized fecal microbial community of female migratory Tibetan antelope in the late pregnancy and postpartum periods using 16S rRNA gene sequencing and quantified fecal glucocorticoids (GCs) and triiodothyronine (T3) metabolite concentrations through enzyme immunoassays to identify the associations between maternal gut microbiota and physiological changes related with reproduction. We found that the fecal microbiota of Tibetan antelope was dominated by Firmicutes and Bacteroidetes. The microbial composition was significantly altered during the transition from late pregnancy to the postpartum period. Fecal T3 concentration was significantly higher in the postpartum period compared to late pregnancy, whereas GC metabolite concentration did not significantly differ between two reproductive states. We identified six genera (Anaerofustis, Bacteroides, Coprococcus_2, Ruminiclostridium_5, Ruminococcaceae_UCG-007, and Tyzzerella) that were significantly associated with reproductive states. We also found two genera (Christensenellaceae_R-7_group and Rikenellaceae_RC9_gut_group) significantly associated with GC metabolite concentration and two genera (Agathobacter and Papillibacter) significantly associated with T3 metabolite concentration, though these correlations were weak with coefficient values ranging from - 0.007 to 0.03. Our results indicate that many members of the gut microbiota are associated with the physiological changes in the transition from late pregnancy to the postpartum period, likely reflecting the metabolic and immune system dynamics during the periparturition period. This study highlights the importance of integrating microbiota, hormones and migration pattern to study the reproductive health of wildlife. By establishing a baseline of the physiological changes during the migration/periparturition period, we can have a better understanding of the impacts of increasing human activities on the Tibetan Plateau on the reproductive health of Tibetan antelope.
关键词	NONINVASIVE MEASUREMENT METABOLIC-CHANGES THYROID-HORMONE DIVERSE ARRAY PREGNANCY POSTPARTUM MAMMALS OVERWEIGHT LACTATION EXCRETION
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000605905300003
来源期刊	CURRENT MICROBIOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254637
作者单位	[Shi, Yue; Wasser, Samuel K.] Univ Washington, Dept Biol, Box 351800, Seattle, WA 98195 USA; [Miao, Zi-Yan; Su, Jian-Ping] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Anim Ecol Genom, 23 Xinning Rd, Xining 810008, Qinghai, Peoples R China; [Miao, Zi-Yan] Museum Nat Resources Qinghai Prov, Xining 810008, Qinghai, Peoples R China; [Shi, Yue] Univ Alaska Fairbanks, Coll Fisheries & Ocean Sci, 17101 Point Lena Loop Rd, Juneau, AK 99801 USA
推荐引用方式 GB/T 7714	Shi, Yue,Miao, Zi-Yan,Su, Jian-Ping,et al. Shift of Maternal Gut Microbiota of Tibetan Antelope (Pantholops hodgsonii) During the Periparturition Period[J]. 中国科学院西北生态环境资源研究院,2021,78(2).
APA	Shi, Yue,Miao, Zi-Yan,Su, Jian-Ping,&Wasser, Samuel K..(2021).Shift of Maternal Gut Microbiota of Tibetan Antelope (Pantholops hodgsonii) During the Periparturition Period.CURRENT MICROBIOLOGY,78(2).
MLA	Shi, Yue,et al."Shift of Maternal Gut Microbiota of Tibetan Antelope (Pantholops hodgsonii) During the Periparturition Period".CURRENT MICROBIOLOGY 78.2(2021).