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DOI	10.1016/j.colsurfb.2021.111973
	Synthesis of charged chitosan nanoparticles as functional biolubricant
	Yang, Lumin; Zhao, Xiaoduo; Zhang, Jing; Ma, Shuanhong; Jiang, Lei; Wei, Qiangbing; Cai, Meirong; Zhou, Feng
通讯作者	Ma, SH ; Zhou, F (通讯作者)，Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China.
发表日期	2021
ISSN	0927-7765
EISSN	1873-4367
卷号	206
英文摘要	Osteoarthritis has been a major disease in recent years, which is mainly related to the breakdown of the lubrication function of the cartilage sliding interface, along with the inflammation of the joint capsule. In this paper, one kind of novel biomimetic nanoparticles (NPs) lubricant, named CS-PS, is synthesized through chemically grafting hydrophilic sulfonic acid (SO3-) groups onto the surface of biocompatible and biodegradable chitosan (CS) NPs. Compared with control CS NPs, the as-synthesized CS-PS NPs exhibits excellent hydration and stability because of negatively charged surface zeta potential, along with extraordinary lubrication performance in water for realizing a super-low friction coefficient (COF) as similar to 0.01 at the sliding interface of PDMS elastomer-Ti6Al4V disk. Correspondingly, the CS-PS NPs can also be used as a drug carrier for aspirin, which presents very good drug loading and release behavior in PBS (pH = 7.4). MCS cells culture experiment proves that this kind of novel lubricant is nontoxic and biocompatible, for which may be expected to use as potential articular injective material for the treatment of osteoarthritis.
关键词	KNEE OSTEOARTHRITIS LUBRICATION MANAGEMENT
英文关键词	Surface modification; Nanoparticles; Osteoarthritis; Water lubrication; Drug release
语种	英语
WOS研究方向	Biophysics ; Chemistry ; Materials Science
WOS类目	Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS记录号	WOS:000693561800001
来源期刊	COLLOIDS AND SURFACES B-BIOINTERFACES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254632
作者单位	[Yang, Lumin; Zhao, Xiaoduo; Ma, Shuanhong; Cai, Meirong; Zhou, Feng] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China; [Zhang, Jing; Jiang, Lei] Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Peoples R China; [Wei, Qiangbing] Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab EcoEnvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Peoples R China
推荐引用方式 GB/T 7714	Yang, Lumin,Zhao, Xiaoduo,Zhang, Jing,et al. Synthesis of charged chitosan nanoparticles as functional biolubricant[J]. 中国科学院西北生态环境资源研究院,2021,206.
APA	Yang, Lumin.,Zhao, Xiaoduo.,Zhang, Jing.,Ma, Shuanhong.,Jiang, Lei.,...&Zhou, Feng.(2021).Synthesis of charged chitosan nanoparticles as functional biolubricant.COLLOIDS AND SURFACES B-BIOINTERFACES,206.
MLA	Yang, Lumin,et al."Synthesis of charged chitosan nanoparticles as functional biolubricant".COLLOIDS AND SURFACES B-BIOINTERFACES 206(2021).