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| DOI | 10.1016/j.molliq.2021.116397 |
| Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery | |
| Peng, Jingyi; Zhang, Lei; Gong, Peiwei; Xu, Wenyu; Qi, Changmin; Yu, Congmin; Liu, Xicheng; Shen, Duyi; Liu, Zhe; You, Jinmao | |
| 通讯作者 | Gong, PW ; Liu, Z (通讯作者)，Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China. |
| 发表日期 | 2021 |
| ISSN | 0167-7322 |
| EISSN | 1873-3166 |
| 卷号 | 337 |
| 英文摘要 | Inspired by the structure of leaves that possesses hollow veins and mesophyll with high surface area, a novel MnO2-based biomimetic fluorescence-switchable nanosystem was constructed to visually monitor drug loading and deliver mixed drugs. Leaf-like MnO2 with hollow tubes and wrinkled sheets was first synthesized, and further modified by dopamine for effective loading both hydrophilic and hydrophobic drugs. The degradation of MnO2 can be well controlled by adjusting the thickness of polydopamine film, and the strong pi-pi interactions between them also establish a strong fluorescence resonance energy transfer system, which allows us unprecedentedly to conveniently monitor drug loading process under naked eyes just by judging solution color changes. Additionally, in vitro experimental results demonstrate that the co-drug loaded system exhibits outstanding cancer therapy effect than single therapy, and we also report its first experimental example for effectively anti-cancer migration. The novel biomimetic synthesis method, effective co-loading different drugs with a visual pattern, and much better anticancer and anti-migration effect make our work potentially valuable in many fields. (C) 2021 Elsevier B.V. All rights reserved. |
| 英文关键词 | Fluorescent switches; Surface modification; Visual loading; Drug delivery |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Physics |
| WOS类目 | Chemistry, Physical ; Physics, Atomic, Molecular & Chemical |
| WOS记录号 | WOS:000681039600047 |
| 来源期刊 | JOURNAL OF MOLECULAR LIQUIDS
 |
| 来源机构 | 中国科学院西北生态环境资源研究院 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/254616 |
| 作者单位 | [Peng, Jingyi; Zhang, Lei; Gong, Peiwei; Xu, Wenyu; Qi, Changmin; Yu, Congmin; Liu, Xicheng; Shen, Duyi; Liu, Zhe; You, Jinmao] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China; [Gong, Peiwei] Northwestern Polytech Univ, Ctr Adv Lubricat & Seal Mat, State Key Lab Solidificat Proc, Xian 710072, Peoples R China; [You, Jinmao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Jingyi,Zhang, Lei,Gong, Peiwei,et al. Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery[J]. 中国科学院西北生态环境资源研究院,2021,337. |
| APA | Peng, Jingyi.,Zhang, Lei.,Gong, Peiwei.,Xu, Wenyu.,Qi, Changmin.,...&You, Jinmao.(2021).Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery.JOURNAL OF MOLECULAR LIQUIDS,337. |
| MLA | Peng, Jingyi,et al."Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery".JOURNAL OF MOLECULAR LIQUIDS 337(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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