气候变化领域集成服务门户(CCPortal): Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds

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DOI	10.1080/10495398.2021.2005616
	Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds
	Wang, Xiaogang; Wang, Yiru; Cao, Xiukai; Huang, Yongzhen; Li, Pi; Lan, Xianyong; Buren, Chaogetu; Hu, Linyong; Chen, Hong
通讯作者	Hu, LY (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China. ; Chen, H (通讯作者)，Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
发表日期	2020
ISSN	1049-5398
EISSN	1532-2378
英文摘要	Copy number variation (CNV) is one kind of genomic structure variations and presents as gains and losses of genomic fragments. More recently, we have made an atlas of CNV maps for livestock. In the future, it is a primary focus to determine the phenotypic effects of candidate CNVs. Lysine Acetyltransferase 6 A (KAT6A) is a protein coding gene and plays a critical role in many cellular processes. However, the effects of KAT6A CNVs on sheep body measurements remains unknown. In this study, we performed quantitative polymerase chain reaction (qPCR) to detect the presences and distributions of three CNV regions within KAT6A gene in 672 sheep from four Chinese breeds. Association analysis indicated that the three CNVs of KAT6A gene were significantly associated with body measurement(s) in Small-tailed Han sheep (STH) and Hu sheep (HU) (p < 0.05), while no effects on Large-tailed Han sheep (LTH) were observed (p > 0.05) were observed. Additionally, only one CNV was significantly associated with body measurement (body length) in Chaka sheep (CK) (p < 0.05). Our study provided evidence that the CNV(s) of KAT6A gene could be used as candidate marker(s) for molecular breedings of STH, HU, and CK breeds.
关键词	MOZ ACETYLATION POPULATION EXPRESSION MUTATIONS GENOMES P53
英文关键词	CNVs; sheep; KAT6A gene; growth traits; association
语种	英语
WOS研究方向	Agriculture ; Biotechnology & Applied Microbiology
WOS类目	Agriculture, Dairy & Animal Science ; Biotechnology & Applied Microbiology
WOS记录号	WOS:000723457900001
来源期刊	ANIMAL BIOTECHNOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254510
作者单位	[Wang, Xiaogang; Wang, Yiru; Huang, Yongzhen; Lan, Xianyong; Chen, Hong] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling, Shaanxi, Peoples R China; [Cao, Xiukai] Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou, Jiangsu, Peoples R China; [Li, Pi; Hu, Linyong] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China; [Buren, Chaogetu] Anim Dis Control Ctr Haixi Mongolian & Tibetan Au, Delingha, Qinghai, Peoples R China; [Chen, Hong] Xinjiang Agr Univ, Coll Anim Sci, Urumqi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaogang,Wang, Yiru,Cao, Xiukai,et al. Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds[J]. 中国科学院西北生态环境资源研究院,2020.
APA	Wang, Xiaogang.,Wang, Yiru.,Cao, Xiukai.,Huang, Yongzhen.,Li, Pi.,...&Chen, Hong.(2020).Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds.ANIMAL BIOTECHNOLOGY.
MLA	Wang, Xiaogang,et al."Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds".ANIMAL BIOTECHNOLOGY (2020).