气候变化领域集成服务门户(CCPortal): Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment

CCPortal

DOI	10.1021/acsami.1c03409
	Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment
	Li, Min; Lan, Xi; Han, Ximei; Shi, Shuo; Sun, Hao; Kang, Yi; Dan, Jie; Sun, Jing; Zhang, Wentao; Wang, Jianlong
通讯作者	Zhang, WT ; Wang, JL (通讯作者)，Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
发表日期	2021
ISSN	1944-8244
EISSN	1944-8252
起始页码	29269
结束页码	29280
卷号	13 期号:25
英文摘要	Nanoantibacterial agents based on catalytic activity were limited due to the low levels of endogenous H2O2 in the microenvironment of bacterial biofilms. However, the additional H2O2 will trigger more side effects to healthy surroundings, which is still a great challenge. Herein, we report an acid-induced self-catalyzing platform based on dextran-coated copper peroxide nanoaggregates (DCPNAs) for antibiofilm and local infection therapy applications. The dextran-functionalized DCPNAs were mediated and conveniently purified via a dextran and ethanol precipitation method, which can also cluster nanodots into nanoaggregates and show good penetrability as well as biocompatibility. Bacterial biofilms were inhibited and destroyed by the reactive oxygen species generated from the Fenton reaction between the Cu2+ and H2O2 released from DCPNAs in an acidic environment, which did not require additional H2O2. As expected, the DCPNAs exhibit low cytotoxicity and excellent acid-induced antibacterial and antibiofilm ability. Moreover, the DCPNAs realized great therapeutic outcomes in the application for in vivo wound healing. The overall excellent properties associated with the DCPNAs highlight that they could be considered as a kind of ideal antimicrobial agents for microbial biofilm infection treatment.
关键词	SILVER NANOPARTICLES IN-VIVO ANTIBACTERIAL SURFACE MEMBRANE
英文关键词	self-catalyzing; antibiofilm; dextran; nanoaggregates; wound healing
语种	英语
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000670430100004
来源期刊	ACS APPLIED MATERIALS & INTERFACES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254463
作者单位	[Li, Min; Lan, Xi; Han, Ximei; Shi, Shuo; Sun, Hao; Kang, Yi; Dan, Jie; Zhang, Wentao; Wang, Jianlong] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China; [Sun, Jing] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Min,Lan, Xi,Han, Ximei,et al. Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment[J]. 中国科学院西北生态环境资源研究院,2021,13(25).
APA	Li, Min.,Lan, Xi.,Han, Ximei.,Shi, Shuo.,Sun, Hao.,...&Wang, Jianlong.(2021).Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment.ACS APPLIED MATERIALS & INTERFACES,13(25).
MLA	Li, Min,et al."Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment".ACS APPLIED MATERIALS & INTERFACES 13.25(2021).