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DOI	10.1016/j.molliq.2021.118000
	Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity
	Wang, Fang; Qi, Xiongwei; Geng, Jiahong; Liu, Xiaoyan; Li, Dong; Zhang, Hui; Zhang, Peng; He, Xiaolei; Li, Baowei; Li, Zhijia; Yu, Ruitao; Yang, Xiaoying; Wang, Guangshuo
通讯作者	Zhang, H ; Li, BW ; Wang, GS (通讯作者)，Hebei Univ Engn, Affiliated Hosp, Dept Med Imaging, Handan 056038, Peoples R China. ; Wang, GS (通讯作者)，Hebei Univ Engn, Sch Mat Sci & Engn, Handan 056038, Peoples R China. ; Yu, RT (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China.
发表日期	2022
ISSN	0167-7322
EISSN	1873-3166
卷号	347
英文摘要	Monodisperse hollow mesoporous Fe3O4 nanospheres have been successfully synthesized via a template-free one-pot solvothermal method under the existence of iron chloride hexahydrate, polyvinylpyrrolidone and urea. A proposed gas-bubble-assisted Ostwald ripening mechanism was allowed to explain the possible fabrication of hollow nanostructures. The formed Fe3O4 nanospheres possessed a narrow particle size distribution with a average hydrodynamic diameter of 392 nm, superparamagnetic characteristics with high saturation magnetization of 74.9 emu/g, as well as the typical mesoporous structures with specific surface area of 27.3 m(2)/g. Furthermore, it was found that the bare hollow mesoporous Fe3O4 nanospheres showed an insignificant cytotoxicity, but exhibited obvious cytotoxic effects towards HeLa cells after being loaded with the anti-cancer drug of DOX, which could be recommended as a promising and effective drug delivery system with high drug loading capacity and pH-responsive feature. The determined maximum drug loading capacity of DOX on this kind of hollow mesoporous Fe3O4 nanospheres was as high as 0.36 +/- 0.04 g/g, which can store and deliver effectively the anticancer drugs to induce death of cancer cells. (C) 2021 Elsevier B.V. All rights reserved.
关键词	IRON-OXIDE NANOPARTICLES MAGNETIC-PROPERTIES MICROSPHERES MICELLES SPHERES
英文关键词	Nanospheres; Solvothermal; Hollow structure; Superparamagnetic; Biomedicine
语种	英语
WOS研究方向	Chemistry ; Physics
WOS类目	Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
WOS记录号	WOS:000754514800010
来源期刊	JOURNAL OF MOLECULAR LIQUIDS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254454
作者单位	[Wang, Fang; Zhang, Hui; Zhang, Peng; He, Xiaolei; Li, Baowei; Li, Zhijia; Wang, Guangshuo] Hebei Univ Engn, Affiliated Hosp, Dept Med Imaging, Handan 056038, Peoples R China; [Qi, Xiongwei; Geng, Jiahong; Liu, Xiaoyan; Wang, Guangshuo] Hebei Univ Engn, Sch Mat Sci & Engn, Handan 056038, Peoples R China; [Li, Dong] Handan Univ, Coll Chem Engn & Mat, Handan 056005, Peoples R China; [Yu, Ruitao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China; [Yang, Xiaoying] Third Hosp Handan, Dept Comp Tomog, Handan 056001, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fang,Qi, Xiongwei,Geng, Jiahong,et al. Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity[J]. 中国科学院西北生态环境资源研究院,2022,347.
APA	Wang, Fang.,Qi, Xiongwei.,Geng, Jiahong.,Liu, Xiaoyan.,Li, Dong.,...&Wang, Guangshuo.(2022).Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity.JOURNAL OF MOLECULAR LIQUIDS,347.
MLA	Wang, Fang,et al."Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity".JOURNAL OF MOLECULAR LIQUIDS 347(2022).