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DOI	10.1039/d1nj02111g
	A ratiometric fluorescence assay for bleomycin based on Cu2+-triggered cascade reactions and nanoparticle-mediated autocatalytic reactions
	Guo, Fujin; Xia, Meng; Sun, Jing; Zhu, Shuyun
通讯作者	Zhu, SY (通讯作者)，Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China.
发表日期	2021
ISSN	1144-0546
EISSN	1369-9261
起始页码	13620
结束页码	13625
卷号	45 期号:30
英文摘要	A simple strategy has been designed for ratiometric fluorescence sensing of BLM on the basis of Cu2+-triggered fluorogenic reactions coupled with nanoparticle-mediated autocatalytic reactions. On one hand, Cu2+ can oxidize ascorbic acid (AA) to produce dehydroascorbic acid (DHAA), which condensates with o-phenylenediamine (OPD) to form fluorescent 3-(dihydroxyethyl) furo[3,4-b]quinoxaline-1-one (DFQ) with strong emission at 436 nm. On the other hand, Cu2+ and OPD undergo a redox reaction to form fluorescent 2,3-diaminophenazine (DAP) showing strong emission at 565 nm and copper nanoparticles (CuNPs) that further catalyze this redox reaction. A ratiometric fluorescence system comes into being due to these two well-resolved emission peaks. Ascribed to the complexation of BLM with Cu2+, larger CuNPs are obtained which weaken the autocatalytic reaction between Cu2+ and OPD. Thus, the fluorescence intensities at 565 nm belonging to DAP decrease while those at 436 nm corresponding to DFQ change slightly. With the fluorescence intensity ratio (F-436/F-565) as a readout, BLM can be detected selectively and sensitively with a detection limit of 50 pM.
关键词	GRAPHENE QUANTUM DOTS LABEL-FREE ASCORBIC-ACID SENSITIVE DETECTION RATIO FLUORESCENCE STRATEGY NANOCLUSTERS OXIDATION SENSOR IONS
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000673152400001
来源期刊	NEW JOURNAL OF CHEMISTRY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254438
作者单位	[Guo, Fujin] Shandong Agr Univ, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control Shandong, Tai An 271018, Shandong, Peoples R China; [Xia, Meng; Zhu, Shuyun] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China; [Sun, Jing] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Guo, Fujin,Xia, Meng,Sun, Jing,et al. A ratiometric fluorescence assay for bleomycin based on Cu2+-triggered cascade reactions and nanoparticle-mediated autocatalytic reactions[J]. 中国科学院西北生态环境资源研究院,2021,45(30).
APA	Guo, Fujin,Xia, Meng,Sun, Jing,&Zhu, Shuyun.(2021).A ratiometric fluorescence assay for bleomycin based on Cu2+-triggered cascade reactions and nanoparticle-mediated autocatalytic reactions.NEW JOURNAL OF CHEMISTRY,45(30).
MLA	Guo, Fujin,et al."A ratiometric fluorescence assay for bleomycin based on Cu2+-triggered cascade reactions and nanoparticle-mediated autocatalytic reactions".NEW JOURNAL OF CHEMISTRY 45.30(2021).