气候变化领域集成服务门户(CCPortal): Facile solvothermal synthesis of monodisperse superparamagnetic mesoporous Fe3O4 & nbsp;nanospheres for pH-responsive controlled drug delivery

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DOI	10.1016/j.colsurfa.2021.126643
	Facile solvothermal synthesis of monodisperse superparamagnetic mesoporous Fe3O4 & nbsp;nanospheres for pH-responsive controlled drug delivery
	Wang, Fang; Geng, Jiahong; Qi, Xiongwei; Zhang, Peng; Zhang, Hui; He, Xiaolei; Li, Zhijia; Yu, Ruitao; Li, Junqiang; Li, Baowei; Wang, Guangshuo
通讯作者	Zhang, H (通讯作者)，Hebei Univ Engn, Affiliated Hosp, Dept Med Imaging, Handan 056038, Peoples R China. ; Wang, GS (通讯作者)，Hebei Univ Engn, Sch Mat Sci & Engn, Handan 056038, Peoples R China. ; Yu, RT (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China.
发表日期	2021
ISSN	0927-7757
EISSN	1873-4359
卷号	622
英文摘要	In the present work, monodisperse Fe3O4 nanospheres with typical mesoporous structures and superparamagnetic characteristics were synthesized through a simple solvothermal approach. Various characterization experiments including SEM, TEM, XRD, XPS, BET and SQUID were performed to investigate in detail the morphology, microstructure, composition and physicochemical properties of the prepared Fe3O4 nanospheres. It was found that the average diameter of Fe3O4 nanospheres was determined to be about 207.3 nm with a relatively narrow size distribution. The analysis of nitrogen adsorption/desorption isotherms indicated that Fe3O4 nanospheres represented typical mesoporous structures having a surface area of 20.68 m2/g. The magnetic property measurements demonstrated that the synthesized nanospheres behaved as superparamagnetic with a high saturation magnetization of 97.5 emu/g. Most importantly, the mesoporous Fe3O4 nanospheres could be utilized as a potential anti-cancer drug carrier for doxorubicin hydrochloride (DOX). The drug loading capacity and in vitro drug release behavior of DOX in phosphate buffered solutions under different pH values (4.0, 5.5 and 7.4) were examined. The results showed that the developed drug delivery system based on mesoporous Fe3O4 nanospheres exhibited a high drug loading capacity and a controlled drug release behavior.
关键词	MAGNETITE NANOPARTICLES CONTROLLED-RELEASE MICROSPHERES IRON
英文关键词	Magnetic nanospheres; Mesoporous structure; Superparamagnetic; Drug delivery
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
WOS记录号	WOS:000657419600004
来源期刊	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254364
作者单位	[Wang, Fang; Zhang, Peng; Zhang, Hui; He, Xiaolei; Li, Zhijia; Li, Junqiang; Li, Baowei] Hebei Univ Engn, Affiliated Hosp, Dept Med Imaging, Handan 056038, Peoples R China; [Geng, Jiahong; Qi, Xiongwei; Wang, Guangshuo] Hebei Univ Engn, Sch Mat Sci & Engn, Handan 056038, Peoples R China; [Yu, Ruitao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China; [Wang, Guangshuo] Nanchang Univ, Coll Chem, Postdoctoral Res Stn Chem Engn & Technol, Nanchang 330031, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fang,Geng, Jiahong,Qi, Xiongwei,et al. Facile solvothermal synthesis of monodisperse superparamagnetic mesoporous Fe3O4 & nbsp;nanospheres for pH-responsive controlled drug delivery[J]. 中国科学院西北生态环境资源研究院,2021,622.
APA	Wang, Fang.,Geng, Jiahong.,Qi, Xiongwei.,Zhang, Peng.,Zhang, Hui.,...&Wang, Guangshuo.(2021).Facile solvothermal synthesis of monodisperse superparamagnetic mesoporous Fe3O4 & nbsp;nanospheres for pH-responsive controlled drug delivery.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,622.
MLA	Wang, Fang,et al."Facile solvothermal synthesis of monodisperse superparamagnetic mesoporous Fe3O4 & nbsp;nanospheres for pH-responsive controlled drug delivery".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 622(2021).